Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome: A randomized clinical trial

Arefe Parvaresh, Roghaye Razavi, Khadijeh Yaghooblo, Akbar Hassanzadeh, Noushin Mohammadifard, Behnood Abbasi, Sayyed Morteza Safavi, Amir Hadi, Cain Clark

Research output: Contribution to journalArticle


Objective: : The aim of present study was to compare the effect of calorie restriction and modified alternate-day fasting diet on treatment of adults with metabolic syndrome.
Design: : This randomized clinical trial was conducted on 70 participants diagnosed with metabolic syndrome.
Setting: : Patients were randomly allocated into 2 groups to follow either calorie restriction or a modified alternate- day fasting diet for 8 weeks. Diets was prescribed by dietitians and specialized for each participant. Anthropometric parameters, blood pressure, fasting plasma glucose, fasting insulin, HOMA-IR and lipid profile were measured at baseline and after trial conclusion.
Results: : 69, out of 70, participants completed the study and were included in the final analysis. The results showed that, compared with calorie restriction, following the modified alternate-day fasting diet significantly reduced body weight (P=0.003), waist circumference (P=0.026), systolic blood pressure (P=0.029) and fasting plasma glucose (P=0.009). However, no significant difference was observed between the 2 groups in triglyceride (P=0.614), total cholesterol (P=0.759), LDL-C (P=0.289), HDL-C (P=0.909), diastolic blood pressure (P=0.262), HOMA- IR (P=0.425) and fasting insulin concentrations (P=0.496). In addition, the participants did not report any complaint due to difficulties with diet adherence when following calorie restriction or modified alternate-day fasting diet.
Conclusions: : the present study suggests that modified alternate-day fasting diet may be a more effective option
in managing body weight, waist circumference, systolic blood pressure, and fasting plasma glucose, compared with common calorie restriction. Further studies are needed to confirm the veracity of our results.
Original languageEnglish
Article number102187
JournalComplementary Therapies in Medicine
Early online date28 Aug 2019
Publication statusPublished - Dec 2019



  • Alternate-day fasting
  • energy restriction
  • anthropometric
  • glycemic index
  • plasma lipids
  • metabolic syndrome x

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