Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome: A randomized clinical trial

Arefe Parvaresh, Roghaye Razavi, Khadijeh Yaghooblo, Akbar Hassanzadeh, Noushin Mohammadifard, Behnood Abbasi, Sayyed Morteza Safavi, Amir Hadi, Cain Clark

Research output: Contribution to journalArticle

Abstract

Objective: : The aim of present study was to compare the effect of calorie restriction and modified alternate-day fasting diet on treatment of adults with metabolic syndrome.
Design: : This randomized clinical trial was conducted on 70 participants diagnosed with metabolic syndrome.
Setting: : Patients were randomly allocated into 2 groups to follow either calorie restriction or a modified alternate- day fasting diet for 8 weeks. Diets was prescribed by dietitians and specialized for each participant. Anthropometric parameters, blood pressure, fasting plasma glucose, fasting insulin, HOMA-IR and lipid profile were measured at baseline and after trial conclusion.
Results: : 69, out of 70, participants completed the study and were included in the final analysis. The results showed that, compared with calorie restriction, following the modified alternate-day fasting diet significantly reduced body weight (P=0.003), waist circumference (P=0.026), systolic blood pressure (P=0.029) and fasting plasma glucose (P=0.009). However, no significant difference was observed between the 2 groups in triglyceride (P=0.614), total cholesterol (P=0.759), LDL-C (P=0.289), HDL-C (P=0.909), diastolic blood pressure (P=0.262), HOMA- IR (P=0.425) and fasting insulin concentrations (P=0.496). In addition, the participants did not report any complaint due to difficulties with diet adherence when following calorie restriction or modified alternate-day fasting diet.
Conclusions: : the present study suggests that modified alternate-day fasting diet may be a more effective option
in managing body weight, waist circumference, systolic blood pressure, and fasting plasma glucose, compared with common calorie restriction. Further studies are needed to confirm the veracity of our results.
Original languageEnglish
Article number102187
Pages (from-to)(In-press)
JournalComplementary Therapies in Medicine
Volume47
Early online date28 Aug 2019
DOIs
Publication statusE-pub ahead of print - 28 Aug 2019

Fingerprint

Fasting
Randomized Controlled Trials
Diet
Blood Pressure
Therapeutics
Waist Circumference
Glucose
Body Weight
Insulin
Nutritionists
Triglycerides
Cholesterol
Lipids

Keywords

  • Alternate-day fasting
  • energy restriction
  • anthropometric
  • glycemic index
  • plasma lipids
  • metabolic syndrome x

Cite this

Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome : A randomized clinical trial. / Parvaresh, Arefe ; Razavi, Roghaye ; Yaghooblo, Khadijeh ; Hassanzadeh, Akbar; Mohammadifard, Noushin; Abbasi, Behnood ; Safavi, Sayyed Morteza ; Hadi, Amir; Clark, Cain.

In: Complementary Therapies in Medicine, Vol. 47, 102187, 28.08.2019, p. (In-press).

Research output: Contribution to journalArticle

Parvaresh, Arefe ; Razavi, Roghaye ; Yaghooblo, Khadijeh ; Hassanzadeh, Akbar ; Mohammadifard, Noushin ; Abbasi, Behnood ; Safavi, Sayyed Morteza ; Hadi, Amir ; Clark, Cain. / Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome : A randomized clinical trial. In: Complementary Therapies in Medicine. 2019 ; Vol. 47. pp. (In-press).
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AU - Razavi, Roghaye

AU - Yaghooblo, Khadijeh

AU - Hassanzadeh, Akbar

AU - Mohammadifard, Noushin

AU - Abbasi, Behnood

AU - Safavi, Sayyed Morteza

AU - Hadi, Amir

AU - Clark, Cain

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AB - Objective: : The aim of present study was to compare the effect of calorie restriction and modified alternate-day fasting diet on treatment of adults with metabolic syndrome.Design: : This randomized clinical trial was conducted on 70 participants diagnosed with metabolic syndrome.Setting: : Patients were randomly allocated into 2 groups to follow either calorie restriction or a modified alternate- day fasting diet for 8 weeks. Diets was prescribed by dietitians and specialized for each participant. Anthropometric parameters, blood pressure, fasting plasma glucose, fasting insulin, HOMA-IR and lipid profile were measured at baseline and after trial conclusion.Results: : 69, out of 70, participants completed the study and were included in the final analysis. The results showed that, compared with calorie restriction, following the modified alternate-day fasting diet significantly reduced body weight (P=0.003), waist circumference (P=0.026), systolic blood pressure (P=0.029) and fasting plasma glucose (P=0.009). However, no significant difference was observed between the 2 groups in triglyceride (P=0.614), total cholesterol (P=0.759), LDL-C (P=0.289), HDL-C (P=0.909), diastolic blood pressure (P=0.262), HOMA- IR (P=0.425) and fasting insulin concentrations (P=0.496). In addition, the participants did not report any complaint due to difficulties with diet adherence when following calorie restriction or modified alternate-day fasting diet.Conclusions: : the present study suggests that modified alternate-day fasting diet may be a more effective optionin managing body weight, waist circumference, systolic blood pressure, and fasting plasma glucose, compared with common calorie restriction. Further studies are needed to confirm the veracity of our results.

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KW - plasma lipids

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