Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome: A randomized clinical trial

Arefe Parvaresh, Roghaye Razavi, Khadijeh Yaghooblo, Akbar Hassanzadeh, Noushin Mohammadifard, Behnood Abbasi, Sayyed Morteza Safavi, Amir Hadi, Cain Clark

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    Objective: : The aim of present study was to compare the effect of calorie restriction and modified alternate-day fasting diet on treatment of adults with metabolic syndrome.
    Design: : This randomized clinical trial was conducted on 70 participants diagnosed with metabolic syndrome.
    Setting: : Patients were randomly allocated into 2 groups to follow either calorie restriction or a modified alternate- day fasting diet for 8 weeks. Diets was prescribed by dietitians and specialized for each participant. Anthropometric parameters, blood pressure, fasting plasma glucose, fasting insulin, HOMA-IR and lipid profile were measured at baseline and after trial conclusion.
    Results: : 69, out of 70, participants completed the study and were included in the final analysis. The results showed that, compared with calorie restriction, following the modified alternate-day fasting diet significantly reduced body weight (P=0.003), waist circumference (P=0.026), systolic blood pressure (P=0.029) and fasting plasma glucose (P=0.009). However, no significant difference was observed between the 2 groups in triglyceride (P=0.614), total cholesterol (P=0.759), LDL-C (P=0.289), HDL-C (P=0.909), diastolic blood pressure (P=0.262), HOMA- IR (P=0.425) and fasting insulin concentrations (P=0.496). In addition, the participants did not report any complaint due to difficulties with diet adherence when following calorie restriction or modified alternate-day fasting diet.
    Conclusions: : the present study suggests that modified alternate-day fasting diet may be a more effective option
    in managing body weight, waist circumference, systolic blood pressure, and fasting plasma glucose, compared with common calorie restriction. Further studies are needed to confirm the veracity of our results.
    Original languageEnglish
    Article number102187
    JournalComplementary Therapies in Medicine
    Early online date28 Aug 2019
    Publication statusPublished - Dec 2019

    Bibliographical note

    NOTICE: this is the author’s version of a work that was accepted for publication in Complementary Therapies in Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Complementary Therapies in Medicine, 47, (2019)] DOI: 10.1016/j.ctim.2019.08.021

    © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International


    • Alternate-day fasting
    • energy restriction
    • anthropometric
    • glycemic index
    • plasma lipids
    • metabolic syndrome x


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