Modification of fecal microbiota as a mediator of effective weight loss and metabolic benefits following bariatric surgery

Dominic Oduro-Donkor, Mark C Turner, Sebastien Farnaud, Derek Renshaw, Ioannis Kyrou, Petra Hanson, John Hattersley, Martin O Weickert, Vinod Menon, Harpal S Randeva, Thomas, M Barber

    Research output: Contribution to journalReview articlepeer-review

    9 Citations (Scopus)


    Introduction: Bariatric surgery (primarily Laparoscopic Sleeve Gastrectomy [LSG] and Roux-en-Y Gastric Bypass [RYGB]) is an efficacious and durable therapeutic option for weight loss in obesity. The mechanisms that mediate weight loss following bariatric surgery remain incompletely understood. Areas covered: Pubmed search of published data on fecal microbiota, metabolic health, LSG, and RYGB. The fecal microbiome plays a key role in the establishment and maintenance of metabolic wellbeing, and may also contribute (through fecal dysbiosis) to metabolic dysfunction. LSG and RYGB both result in characteristic, procedure-specific changes to the fecal microbiota that may mediate at least some of the resultant weight-loss and metabolically beneficial effects, when applied to the management of obesity. Expert opinion: The human fecal microbiome, containing around 100 trillion microbes, evolved over millions of years and interacts symbiotically with its human host. Rodent-based studies have provided insights into the complexities of the gut-microbiome-brain axis. This includes the important role of the gut microbiome in the mediation of normal immunological development, inflammatory pathways, metabolic functioning, hypothalamic appetite regulation, and the absorption of essential nutrients as by-products of bacterial metabolism. Fecal transformation is likely to provide an important therapeutic target for future prevention and management of obesity and metabolic dysfunction.

    Original languageEnglish
    Pages (from-to)363-373
    Number of pages11
    JournalExpert Review of Endocrinology & Metabolism
    Issue number5
    Early online date25 Aug 2020
    Publication statusPublished - 2 Sep 2020


    • Fecal microbiota
    • Roux-en-Y gastric bypass
    • bariatric surgery
    • incretins
    • microbiome
    • obesity
    • sleeve gastrectomy

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism


    Dive into the research topics of 'Modification of fecal microbiota as a mediator of effective weight loss and metabolic benefits following bariatric surgery'. Together they form a unique fingerprint.

    Cite this