Modelling the integrated regulation role of β-adrenergic signaling and CaMKII in human myocyte electrophysiological properties

Ling Dai; Yunliang Zang; Dingchang Zheng; Ruyi Luo; Ling Xia

Modelling the integrated regulation role of β-adrenergic signaling and CaMKII in human myocyte electrophysiological properties

Ling Dai, Yunliang Zang, Dingchang Zheng, Ruyi Luo, Ling Xia

Research output: Contribution to journal › Conference article › peer-review

Abstract

Both β-Adrenergic receptor (β-AR) signaling pathway and Ca ²⁺/Calmodulin-dependent protein kinase II (CaMKII) play important roles in regulating cardiac excitation-contraction coupling. However, the laboratory experiments cannot quantify these regulatory roles easily, computer models have been used as an alternative way. The aim of this study was to use computer models to preliminarily investigate the combined role of β-AR and CaMKII in human cardiac myocyte properties

Original language	English
Pages (from-to)	389-392
Number of pages	4
Journal	Computing in Cardiology
Publication status	Published - 16 Jan 2014
Externally published	Yes
Event	2013 40th Computing in Cardiology Conference, CinC 2013 - Zaragoza, Spain Duration: 22 Sep 2013 → 25 Sep 2013

ASJC Scopus subject areas

Computer Science(all)
Cardiology and Cardiovascular Medicine

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title = "Modelling the integrated regulation role of β-adrenergic signaling and CaMKII in human myocyte electrophysiological properties",

abstract = "Both β-Adrenergic receptor (β-AR) signaling pathway and Ca 2+/Calmodulin-dependent protein kinase II (CaMKII) play important roles in regulating cardiac excitation-contraction coupling. However, the laboratory experiments cannot quantify these regulatory roles easily, computer models have been used as an alternative way. The aim of this study was to use computer models to preliminarily investigate the combined role of β-AR and CaMKII in human cardiac myocyte properties",

author = "Ling Dai and Yunliang Zang and Dingchang Zheng and Ruyi Luo and Ling Xia",

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journal = "Computing in Cardiology",

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note = "2013 40th Computing in Cardiology Conference, CinC 2013 ; Conference date: 22-09-2013 Through 25-09-2013",

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T1 - Modelling the integrated regulation role of β-adrenergic signaling and CaMKII in human myocyte electrophysiological properties

AU - Dai, Ling

AU - Zang, Yunliang

AU - Zheng, Dingchang

AU - Luo, Ruyi

AU - Xia, Ling

PY - 2014/1/16

Y1 - 2014/1/16

N2 - Both β-Adrenergic receptor (β-AR) signaling pathway and Ca 2+/Calmodulin-dependent protein kinase II (CaMKII) play important roles in regulating cardiac excitation-contraction coupling. However, the laboratory experiments cannot quantify these regulatory roles easily, computer models have been used as an alternative way. The aim of this study was to use computer models to preliminarily investigate the combined role of β-AR and CaMKII in human cardiac myocyte properties

AB - Both β-Adrenergic receptor (β-AR) signaling pathway and Ca 2+/Calmodulin-dependent protein kinase II (CaMKII) play important roles in regulating cardiac excitation-contraction coupling. However, the laboratory experiments cannot quantify these regulatory roles easily, computer models have been used as an alternative way. The aim of this study was to use computer models to preliminarily investigate the combined role of β-AR and CaMKII in human cardiac myocyte properties

UR - http://www.scopus.com/inward/record.url?scp=84894170964&partnerID=8YFLogxK

UR - https://www.cinc.org/archives/2013/pdf/0389.pdf

M3 - Conference article

AN - SCOPUS:84894170964

SP - 389

EP - 392

JO - Computing in Cardiology

JF - Computing in Cardiology

SN - 2325-8861

T2 - 2013 40th Computing in Cardiology Conference, CinC 2013

Y2 - 22 September 2013 through 25 September 2013

ER -