Modelling the integrated regulation role of β-adrenergic signaling and CaMKII in human myocyte electrophysiological properties

Ling Dai, Yunliang Zang, Dingchang Zheng, Ruyi Luo, Ling Xia

Research output: Contribution to journalConference article

1 Citation (Scopus)

Abstract

Both β-Adrenergic receptor (β-AR) signaling pathway and Ca 2+/Calmodulin-dependent protein kinase II (CaMKII) play important roles in regulating cardiac excitation-contraction coupling. However, the laboratory experiments cannot quantify these regulatory roles easily, computer models have been used as an alternative way. The aim of this study was to use computer models to preliminarily investigate the combined role of β-AR and CaMKII in human cardiac myocyte properties

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalComputing in Cardiology
Publication statusPublished - 16 Jan 2014
Externally publishedYes
Event2013 40th Computing in Cardiology Conference, CinC 2013 - Zaragoza, Spain
Duration: 22 Sep 201325 Sep 2013

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

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