Modelling the control of cell proliferation by an anti-cancer agent

Reza Ali, Neil Evans, Lee Campbell, Rachel Errington, Keith Godfrey, Paul Smith, Mike Chappell

Research output: Contribution to journalArticle

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Abstract

A mathematical model has been developed which describes human cell growth in the presence of topotecan (TPT), an anti-cancer agent. Previously, a model was developed for the pharmacokinetics (PK) of TPT; this provided a description of the activity of TPT and the subsequent delivery of the active form to the nuclear DNA target. This model is described briefly in this paper. The development of a new pharmacodynamic (PD) model for cell growth, based on a well-known cell cycle model is then discussed. The linking of the PK model to the PD model is considered with respect to the modulation of cell growth. Our PK - PD model has good agreement with in vitro experimental data. In a clinical context, it is intended that the model will be used for discovering routes for drug resistance and eventually as a tool for improving drug treatments for patients.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalMeasurement and Control
Volume40
Issue number1
DOIs
Publication statusPublished - Feb 2007

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Cell Proliferation
Cell proliferation
Cancer
cancer
Pharmacodynamics
Modeling
Pharmacokinetics
Cell growth
Model
Cell
drugs
Drug therapy
Drug Resistance
Cell Cycle
Linking
mathematical models
delivery
Drugs
Modulation
DNA

Bibliographical note

Copyright Sage Publications Ltd.

ASJC Scopus subject areas

  • Instrumentation

Cite this

Ali, R., Evans, N., Campbell, L., Errington, R., Godfrey, K., Smith, P., & Chappell, M. (2007). Modelling the control of cell proliferation by an anti-cancer agent. Measurement and Control, 40(1), 12-15. https://doi.org/10.1177/002029400704000105

Modelling the control of cell proliferation by an anti-cancer agent. / Ali, Reza; Evans, Neil; Campbell, Lee; Errington, Rachel; Godfrey, Keith; Smith, Paul; Chappell, Mike.

In: Measurement and Control, Vol. 40, No. 1, 02.2007, p. 12-15.

Research output: Contribution to journalArticle

Ali, R, Evans, N, Campbell, L, Errington, R, Godfrey, K, Smith, P & Chappell, M 2007, 'Modelling the control of cell proliferation by an anti-cancer agent' Measurement and Control, vol. 40, no. 1, pp. 12-15. https://doi.org/10.1177/002029400704000105
Ali, Reza ; Evans, Neil ; Campbell, Lee ; Errington, Rachel ; Godfrey, Keith ; Smith, Paul ; Chappell, Mike. / Modelling the control of cell proliferation by an anti-cancer agent. In: Measurement and Control. 2007 ; Vol. 40, No. 1. pp. 12-15.
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