TY - JOUR
T1 - Modelling the control of cell proliferation by an anti-cancer agent
AU - Ali, Reza
AU - Evans, Neil
AU - Campbell, Lee
AU - Errington, Rachel
AU - Godfrey, Keith
AU - Smith, Paul
AU - Chappell, Mike
N1 - Copyright Sage Publications Ltd.
PY - 2007/2
Y1 - 2007/2
N2 - A mathematical model has been developed which describes human cell growth in the presence of topotecan (TPT), an anti-cancer agent. Previously, a model was developed for the pharmacokinetics (PK) of TPT; this provided a description of the activity of TPT and the subsequent delivery of the active form to the nuclear DNA target. This model is described briefly in this paper. The development of a new pharmacodynamic (PD) model for cell growth, based on a well-known cell cycle model is then discussed. The linking of the PK model to the PD model is considered with respect to the modulation of cell growth. Our PK - PD model has good agreement with in vitro experimental data. In a clinical context, it is intended that the model will be used for discovering routes for drug resistance and eventually as a tool for improving drug treatments for patients.
AB - A mathematical model has been developed which describes human cell growth in the presence of topotecan (TPT), an anti-cancer agent. Previously, a model was developed for the pharmacokinetics (PK) of TPT; this provided a description of the activity of TPT and the subsequent delivery of the active form to the nuclear DNA target. This model is described briefly in this paper. The development of a new pharmacodynamic (PD) model for cell growth, based on a well-known cell cycle model is then discussed. The linking of the PK model to the PD model is considered with respect to the modulation of cell growth. Our PK - PD model has good agreement with in vitro experimental data. In a clinical context, it is intended that the model will be used for discovering routes for drug resistance and eventually as a tool for improving drug treatments for patients.
UR - http://www.scopus.com/inward/record.url?scp=33947144247&partnerID=8YFLogxK
U2 - 10.1177/002029400704000105
DO - 10.1177/002029400704000105
M3 - Article
AN - SCOPUS:33947144247
SN - 0020-2940
VL - 40
SP - 12
EP - 15
JO - Measurement and Control
JF - Measurement and Control
IS - 1
ER -
