Modelling the control of cell proliferation by an anti-cancer agent

Reza Ali, Neil Evans, Lee Campbell, Rachel Errington, Keith Godfrey, Paul Smith, Mike Chappell

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Abstract

A mathematical model has been developed which describes human cell growth in the presence of topotecan (TPT), an anti-cancer agent. Previously, a model was developed for the pharmacokinetics (PK) of TPT; this provided a description of the activity of TPT and the subsequent delivery of the active form to the nuclear DNA target. This model is described briefly in this paper. The development of a new pharmacodynamic (PD) model for cell growth, based on a well-known cell cycle model is then discussed. The linking of the PK model to the PD model is considered with respect to the modulation of cell growth. Our PK - PD model has good agreement with in vitro experimental data. In a clinical context, it is intended that the model will be used for discovering routes for drug resistance and eventually as a tool for improving drug treatments for patients.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalMeasurement and Control
Volume40
Issue number1
DOIs
Publication statusPublished - Feb 2007

Bibliographical note

Copyright Sage Publications Ltd.

ASJC Scopus subject areas

  • Instrumentation

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    Ali, R., Evans, N., Campbell, L., Errington, R., Godfrey, K., Smith, P., & Chappell, M. (2007). Modelling the control of cell proliferation by an anti-cancer agent. Measurement and Control, 40(1), 12-15. https://doi.org/10.1177/002029400704000105