Midlife and the menopause transition in type 2 diabetes mellitus prevention

Maxine E Whelan; Sathish Thirunavukkarasu; Karen Pearce; David W Dunstan; Simon J Griffin; Susan R Davis; Annice Mukherjee; Robyn J Tapp

doi:10.1038/s41574-025-01215-8

Midlife and the menopause transition in type 2 diabetes mellitus prevention

Maxine E Whelan
, Sathish Thirunavukkarasu
, Karen Pearce
, David W Dunstan
, Simon J Griffin
, Susan R Davis
, Annice Mukherjee
, Robyn J Tapp

Emory University
Deakin University
The Australian Centre for Behavioural Research in Diabetes
Baker IDI Heart and Diabetes Institute
University of Cambridge
Monash University
Alfred Health
University of Melbourne

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Physiological changes in female individuals during the menopause transition influence cardiometabolic health and type 2 diabetes mellitus (T2DM) incidence. T2DM prevention programmes during midlife among individuals who are at high risk are cost effective but, we suggest, could be enhanced by consideration of the menopause transition and other sex-specific differences in T2DM prevention strategies.

Original language	English
Pages (from-to)	(In-Press)
Journal	Nature Reviews Endocrinology
Volume	(In-Press)
Early online date	1 Dec 2025
DOIs	https://doi.org/10.1038/s41574-025-01215-8
Publication status	E-pub ahead of print - 1 Dec 2025

Bibliographical note

Publisher Copyright:
© Springer Nature Limited 2025.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s41574-025-01215-8

Cite this

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abstract = "Physiological changes in female individuals during the menopause transition influence cardiometabolic health and type 2 diabetes mellitus (T2DM) incidence. T2DM prevention programmes during midlife among individuals who are at high risk are cost effective but, we suggest, could be enhanced by consideration of the menopause transition and other sex-specific differences in T2DM prevention strategies.",

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AU - Thirunavukkarasu, Sathish

AU - Pearce, Karen

AU - Dunstan, David W

AU - Griffin, Simon J

AU - Davis, Susan R

AU - Mukherjee, Annice

AU - Tapp, Robyn J

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N2 - Physiological changes in female individuals during the menopause transition influence cardiometabolic health and type 2 diabetes mellitus (T2DM) incidence. T2DM prevention programmes during midlife among individuals who are at high risk are cost effective but, we suggest, could be enhanced by consideration of the menopause transition and other sex-specific differences in T2DM prevention strategies.

AB - Physiological changes in female individuals during the menopause transition influence cardiometabolic health and type 2 diabetes mellitus (T2DM) incidence. T2DM prevention programmes during midlife among individuals who are at high risk are cost effective but, we suggest, could be enhanced by consideration of the menopause transition and other sex-specific differences in T2DM prevention strategies.

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Midlife and the menopause transition in type 2 diabetes mellitus prevention

Abstract

Bibliographical note

UN SDGs

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