Membrane proteins by accident or design

John Simms, Paula J Booth

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Protein design is a valuable tool to create bespoke proteins with desired properties as well as for investigating sequence, structure and function relationships. Membrane protein design is a burgeoning field that is hampered by the lack of high-resolution structural information. In spite of these shortcomings, computational methods have offered a route towards blueprints for these hydrophobic proteins. Advances in structural scoring and sampling methods are enabling more accurate predictions of a folded structure from the primary amino acid sequence. This review highlights a number of novel studies focusing on the methods and information used to successfully design membrane proteins.

Original languageEnglish
Pages (from-to)976-981
Number of pages6
JournalCurrent Opinion in Chemical Biology
Issue number6
Publication statusPublished - Dec 2013


  • Amino Acid Sequence
  • Animals
  • Computer Simulation
  • Humans
  • Membrane Proteins
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation
  • Protein Engineering
  • Protein Folding
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review


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