Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Esther Molina-Montes, María José Sánchez, Genevieve Buckland, H. B. Bueno-De-Mesquita, Elisabete Weiderpass, Pilar Amiano, Petra A. Wark, Tilman Kühn, Verena Katzke, José María Huerta, Eva Ardanaz, José Ramón Quirós, Aurélie Affret, Mathilde His, Marie Christine Boutron-Ruault, Petra H. Peeters, Weimin Ye, Malin Sund, Heiner Boeing, Khalid Iqbal & 23 others Bodil Ohlsson, Emily Sonestedt, Anne Tjønneland, Kristina E N Petersen, Ruth C. Travis, Guri Skeie, Claudia Agnoli, Salvatore Panico, Domenico Palli, Rosario Tumino, Carlotta Sacerdote, Heinz Freisling, Inge Huybrechts, Kim Overvad, Antonia Trichopoulou, Christina Bamia, Effie Vasilopoulou, Nick Wareham, Kay Tee Khaw, Amanda J. Cross, Heather A. Ward, Elio Riboli, Eric J. Duell

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    Abstract

    Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs).Results:Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern.Conclusions:A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

    Original languageEnglish
    Pages (from-to)811-820
    Number of pages10
    JournalBritish Journal of Cancer
    Volume116
    Issue number6
    Early online date7 Feb 2017
    DOIs
    Publication statusPublished - 14 Mar 2017

    Fingerprint

    Mediterranean Diet
    Pancreatic Neoplasms
    Neoplasms
    Alcohols
    Confidence Intervals
    Energy Intake
    Body Mass Index
    Smoking
    Proportional Hazards Models

    Keywords

    • cohort study
    • Mediterranean diet
    • pancreatic cancer

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

    Cite this

    Molina-Montes, E., Sánchez, M. J., Buckland, G., Bueno-De-Mesquita, H. B., Weiderpass, E., Amiano, P., ... Duell, E. J. (2017). Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. British Journal of Cancer, 116(6), 811-820. https://doi.org/10.1038/bjc.2017.14

    Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. / Molina-Montes, Esther; Sánchez, María José; Buckland, Genevieve; Bueno-De-Mesquita, H. B.; Weiderpass, Elisabete; Amiano, Pilar; Wark, Petra A.; Kühn, Tilman; Katzke, Verena; Huerta, José María; Ardanaz, Eva; Quirós, José Ramón; Affret, Aurélie; His, Mathilde; Boutron-Ruault, Marie Christine; Peeters, Petra H.; Ye, Weimin; Sund, Malin; Boeing, Heiner; Iqbal, Khalid; Ohlsson, Bodil; Sonestedt, Emily; Tjønneland, Anne; Petersen, Kristina E N; Travis, Ruth C.; Skeie, Guri; Agnoli, Claudia; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Sacerdote, Carlotta; Freisling, Heinz; Huybrechts, Inge; Overvad, Kim; Trichopoulou, Antonia; Bamia, Christina; Vasilopoulou, Effie; Wareham, Nick; Khaw, Kay Tee; Cross, Amanda J.; Ward, Heather A.; Riboli, Elio; Duell, Eric J.

    In: British Journal of Cancer, Vol. 116, No. 6, 14.03.2017, p. 811-820.

    Research output: Contribution to journalArticle

    Molina-Montes, E, Sánchez, MJ, Buckland, G, Bueno-De-Mesquita, HB, Weiderpass, E, Amiano, P, Wark, PA, Kühn, T, Katzke, V, Huerta, JM, Ardanaz, E, Quirós, JR, Affret, A, His, M, Boutron-Ruault, MC, Peeters, PH, Ye, W, Sund, M, Boeing, H, Iqbal, K, Ohlsson, B, Sonestedt, E, Tjønneland, A, Petersen, KEN, Travis, RC, Skeie, G, Agnoli, C, Panico, S, Palli, D, Tumino, R, Sacerdote, C, Freisling, H, Huybrechts, I, Overvad, K, Trichopoulou, A, Bamia, C, Vasilopoulou, E, Wareham, N, Khaw, KT, Cross, AJ, Ward, HA, Riboli, E & Duell, EJ 2017, 'Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort' British Journal of Cancer, vol. 116, no. 6, pp. 811-820. https://doi.org/10.1038/bjc.2017.14
    Molina-Montes E, Sánchez MJ, Buckland G, Bueno-De-Mesquita HB, Weiderpass E, Amiano P et al. Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. British Journal of Cancer. 2017 Mar 14;116(6):811-820. https://doi.org/10.1038/bjc.2017.14
    Molina-Montes, Esther ; Sánchez, María José ; Buckland, Genevieve ; Bueno-De-Mesquita, H. B. ; Weiderpass, Elisabete ; Amiano, Pilar ; Wark, Petra A. ; Kühn, Tilman ; Katzke, Verena ; Huerta, José María ; Ardanaz, Eva ; Quirós, José Ramón ; Affret, Aurélie ; His, Mathilde ; Boutron-Ruault, Marie Christine ; Peeters, Petra H. ; Ye, Weimin ; Sund, Malin ; Boeing, Heiner ; Iqbal, Khalid ; Ohlsson, Bodil ; Sonestedt, Emily ; Tjønneland, Anne ; Petersen, Kristina E N ; Travis, Ruth C. ; Skeie, Guri ; Agnoli, Claudia ; Panico, Salvatore ; Palli, Domenico ; Tumino, Rosario ; Sacerdote, Carlotta ; Freisling, Heinz ; Huybrechts, Inge ; Overvad, Kim ; Trichopoulou, Antonia ; Bamia, Christina ; Vasilopoulou, Effie ; Wareham, Nick ; Khaw, Kay Tee ; Cross, Amanda J. ; Ward, Heather A. ; Riboli, Elio ; Duell, Eric J. / Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. In: British Journal of Cancer. 2017 ; Vol. 116, No. 6. pp. 811-820.
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    title = "Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort",
    abstract = "Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95{\%} confidence intervals (CIs).Results:Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95{\%} CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95{\%} CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern.Conclusions:A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.",
    keywords = "cohort study, Mediterranean diet, pancreatic cancer",
    author = "Esther Molina-Montes and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Genevieve Buckland and Bueno-De-Mesquita, {H. B.} and Elisabete Weiderpass and Pilar Amiano and Wark, {Petra A.} and Tilman K{\"u}hn and Verena Katzke and Huerta, {Jos{\'e} Mar{\'i}a} and Eva Ardanaz and Quir{\'o}s, {Jos{\'e} Ram{\'o}n} and Aur{\'e}lie Affret and Mathilde His and Boutron-Ruault, {Marie Christine} and Peeters, {Petra H.} and Weimin Ye and Malin Sund and Heiner Boeing and Khalid Iqbal and Bodil Ohlsson and Emily Sonestedt and Anne Tj{\o}nneland and Petersen, {Kristina E N} and Travis, {Ruth C.} and Guri Skeie and Claudia Agnoli and Salvatore Panico and Domenico Palli and Rosario Tumino and Carlotta Sacerdote and Heinz Freisling and Inge Huybrechts and Kim Overvad and Antonia Trichopoulou and Christina Bamia and Effie Vasilopoulou and Nick Wareham and Khaw, {Kay Tee} and Cross, {Amanda J.} and Ward, {Heather A.} and Elio Riboli and Duell, {Eric J.}",
    year = "2017",
    month = "3",
    day = "14",
    doi = "10.1038/bjc.2017.14",
    language = "English",
    volume = "116",
    pages = "811--820",
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    TY - JOUR

    T1 - Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

    AU - Molina-Montes, Esther

    AU - Sánchez, María José

    AU - Buckland, Genevieve

    AU - Bueno-De-Mesquita, H. B.

    AU - Weiderpass, Elisabete

    AU - Amiano, Pilar

    AU - Wark, Petra A.

    AU - Kühn, Tilman

    AU - Katzke, Verena

    AU - Huerta, José María

    AU - Ardanaz, Eva

    AU - Quirós, José Ramón

    AU - Affret, Aurélie

    AU - His, Mathilde

    AU - Boutron-Ruault, Marie Christine

    AU - Peeters, Petra H.

    AU - Ye, Weimin

    AU - Sund, Malin

    AU - Boeing, Heiner

    AU - Iqbal, Khalid

    AU - Ohlsson, Bodil

    AU - Sonestedt, Emily

    AU - Tjønneland, Anne

    AU - Petersen, Kristina E N

    AU - Travis, Ruth C.

    AU - Skeie, Guri

    AU - Agnoli, Claudia

    AU - Panico, Salvatore

    AU - Palli, Domenico

    AU - Tumino, Rosario

    AU - Sacerdote, Carlotta

    AU - Freisling, Heinz

    AU - Huybrechts, Inge

    AU - Overvad, Kim

    AU - Trichopoulou, Antonia

    AU - Bamia, Christina

    AU - Vasilopoulou, Effie

    AU - Wareham, Nick

    AU - Khaw, Kay Tee

    AU - Cross, Amanda J.

    AU - Ward, Heather A.

    AU - Riboli, Elio

    AU - Duell, Eric J.

    PY - 2017/3/14

    Y1 - 2017/3/14

    N2 - Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs).Results:Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern.Conclusions:A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

    AB - Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs).Results:Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern.Conclusions:A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

    KW - cohort study

    KW - Mediterranean diet

    KW - pancreatic cancer

    U2 - 10.1038/bjc.2017.14

    DO - 10.1038/bjc.2017.14

    M3 - Article

    VL - 116

    SP - 811

    EP - 820

    JO - British Journal of Cancer

    JF - British Journal of Cancer

    SN - 0007-0920

    IS - 6

    ER -