Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: A prospective cohort study (The Netherlands)

Margreet Lüchtenborg, Matty P. Weijenberg, Anton F P M De Goeij, Petra A. Wark, Mirian Brink, Guido M J M Roemen, Marjolein H F M Lentjes, Adriaan P. De Bruïne, R. Alexandra Goldbohm, Pieter Van't Veer, Piet A. Van Den Brandt

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    Abstract

    Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. 

    Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results: Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10-2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. 

    Conclusions: Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour.

    Original languageEnglish
    Pages (from-to)1041-1054
    Number of pages14
    JournalCancer Causes and Control
    Volume16
    Issue number9
    DOIs
    Publication statusPublished - Nov 2005

    Fingerprint

    APC Genes
    Rectal Neoplasms
    Netherlands
    Colonic Neoplasms
    Meat
    Fishes
    Cohort Studies
    Prospective Studies
    Mutation
    Colon
    Mutation Rate
    Confidence Intervals
    Neoplasms
    Meat Products
    Incidence

    Keywords

    • Adenomatous polyposis coli
    • Colorectal cancer
    • hMLH1
    • Meat
    • Mutation

    ASJC Scopus subject areas

    • Oncology
    • Epidemiology
    • Cancer Research

    Cite this

    Lüchtenborg, M., Weijenberg, M. P., De Goeij, A. F. P. M., Wark, P. A., Brink, M., Roemen, G. M. J. M., ... Van Den Brandt, P. A. (2005). Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: A prospective cohort study (The Netherlands). Cancer Causes and Control, 16(9), 1041-1054. https://doi.org/10.1007/s10552-005-0239-0

    Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer : A prospective cohort study (The Netherlands). / Lüchtenborg, Margreet; Weijenberg, Matty P.; De Goeij, Anton F P M; Wark, Petra A.; Brink, Mirian; Roemen, Guido M J M; Lentjes, Marjolein H F M; De Bruïne, Adriaan P.; Goldbohm, R. Alexandra; Van't Veer, Pieter; Van Den Brandt, Piet A.

    In: Cancer Causes and Control, Vol. 16, No. 9, 11.2005, p. 1041-1054.

    Research output: Contribution to journalArticle

    Lüchtenborg, M, Weijenberg, MP, De Goeij, AFPM, Wark, PA, Brink, M, Roemen, GMJM, Lentjes, MHFM, De Bruïne, AP, Goldbohm, RA, Van't Veer, P & Van Den Brandt, PA 2005, 'Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: A prospective cohort study (The Netherlands)' Cancer Causes and Control, vol. 16, no. 9, pp. 1041-1054. https://doi.org/10.1007/s10552-005-0239-0
    Lüchtenborg, Margreet ; Weijenberg, Matty P. ; De Goeij, Anton F P M ; Wark, Petra A. ; Brink, Mirian ; Roemen, Guido M J M ; Lentjes, Marjolein H F M ; De Bruïne, Adriaan P. ; Goldbohm, R. Alexandra ; Van't Veer, Pieter ; Van Den Brandt, Piet A. / Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer : A prospective cohort study (The Netherlands). In: Cancer Causes and Control. 2005 ; Vol. 16, No. 9. pp. 1041-1054.
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    abstract = "Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results: Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95{\%} confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95{\%} CI 1.10-2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95{\%} CI 1.10-2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. Conclusions: Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour.",
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    T1 - Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer

    T2 - A prospective cohort study (The Netherlands)

    AU - Lüchtenborg, Margreet

    AU - Weijenberg, Matty P.

    AU - De Goeij, Anton F P M

    AU - Wark, Petra A.

    AU - Brink, Mirian

    AU - Roemen, Guido M J M

    AU - Lentjes, Marjolein H F M

    AU - De Bruïne, Adriaan P.

    AU - Goldbohm, R. Alexandra

    AU - Van't Veer, Pieter

    AU - Van Den Brandt, Piet A.

    PY - 2005/11

    Y1 - 2005/11

    N2 - Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results: Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10-2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. Conclusions: Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour.

    AB - Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results: Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10-2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. Conclusions: Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour.

    KW - Adenomatous polyposis coli

    KW - Colorectal cancer

    KW - hMLH1

    KW - Meat

    KW - Mutation

    U2 - 10.1007/s10552-005-0239-0

    DO - 10.1007/s10552-005-0239-0

    M3 - Article

    VL - 16

    SP - 1041

    EP - 1054

    JO - Cancer Causes and Control

    JF - Cancer Causes and Control

    SN - 0957-5243

    IS - 9

    ER -