TY - JOUR
T1 - Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer
T2 - A prospective cohort study (The Netherlands)
AU - Lüchtenborg, Margreet
AU - Weijenberg, Matty P.
AU - De Goeij, Anton F P M
AU - Wark, Petra A.
AU - Brink, Mirian
AU - Roemen, Guido M J M
AU - Lentjes, Marjolein H F M
AU - De Bruïne, Adriaan P.
AU - Goldbohm, R. Alexandra
AU - Van't Veer, Pieter
AU - Van Den Brandt, Piet A.
PY - 2005/11
Y1 - 2005/11
N2 - Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results: Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10-2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. Conclusions: Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour.
AB - Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results: Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10-2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. Conclusions: Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour.
KW - Adenomatous polyposis coli
KW - Colorectal cancer
KW - hMLH1
KW - Meat
KW - Mutation
U2 - 10.1007/s10552-005-0239-0
DO - 10.1007/s10552-005-0239-0
M3 - Article
C2 - 16184469
AN - SCOPUS:25144482301
SN - 0957-5243
VL - 16
SP - 1041
EP - 1054
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 9
ER -
