Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: A prospective cohort study (The Netherlands)

Margreet Lüchtenborg, Matty P. Weijenberg, Anton F P M De Goeij, Petra A. Wark, Mirian Brink, Guido M J M Roemen, Marjolein H F M Lentjes, Adriaan P. De Bruïne, R. Alexandra Goldbohm, Pieter Van't Veer, Piet A. Van Den Brandt

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    Abstract

    Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. 

    Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results: Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10-2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. 

    Conclusions: Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour.

    Original languageEnglish
    Pages (from-to)1041-1054
    Number of pages14
    JournalCancer Causes and Control
    Volume16
    Issue number9
    DOIs
    Publication statusPublished - Nov 2005

    Keywords

    • Adenomatous polyposis coli
    • Colorectal cancer
    • hMLH1
    • Meat
    • Mutation

    ASJC Scopus subject areas

    • Oncology
    • Epidemiology
    • Cancer Research

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  • Cite this

    Lüchtenborg, M., Weijenberg, M. P., De Goeij, A. F. P. M., Wark, P. A., Brink, M., Roemen, G. M. J. M., ... Van Den Brandt, P. A. (2005). Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: A prospective cohort study (The Netherlands). Cancer Causes and Control, 16(9), 1041-1054. https://doi.org/10.1007/s10552-005-0239-0