Maximal Oxygen Uptake Is Achieved in Hypoxia but Not Normoxia during an Exhaustive Severe Intensity Run

Matthew I Black, Christopher R Potter, Jo Corbett, Cain C T Clark, Stephen B Draper

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3 Citations (Scopus)
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Highly aerobically trained individuals are unable to achieve maximal oxygen uptake ([Formula: see text]) during exhaustive running lasting ~2 min, instead [Formula: see text] plateaus below [Formula: see text] after ~1 min. Hypoxia offers the opportunity to study the ([Formula: see text]) response to an exhaustive run relative to a hypoxia induced reduction in [Formula: see text]. The aim of this study was to explore whether there is a difference in the percentage of [Formula: see text] achieved (during a 2 min exhaustive run) in normoxia and hypoxia. Fourteen competitive middle distance runners (normoxic [Formula: see text] 67.0 ± 5.2 completed exhaustive treadmill ramp tests and constant work rate (CWR) tests in normoxia and hypoxia (F i O2 0.13). The [Formula: see text] data from the CWR tests were modeled using a single exponential function. End exercise normoxic CWR [Formula: see text] was less than normoxic [Formula: see text] (86 ± 6% ramp, P < 0.001). During the hypoxic CWR test, hypoxic [Formula: see text] was achieved (102 ± 8% ramp, P = 0.490). The phase II time constant was greater in hypoxia (12.7 ± 2.8 s) relative to normoxia (10.4 ± 2.6 s) (P = 0.029). The results demonstrate that highly aerobically trained individuals cannot achieve [Formula: see text] during exhaustive severe intensity treadmill running in normoxia, but can achieve the lower [Formula: see text] in hypoxia despite a slightly slower [Formula: see text] response.

Original languageEnglish
Article number96
Number of pages7
JournalFrontiers in Physiology
Publication statusPublished - 21 Feb 2017
Externally publishedYes

Bibliographical note

Copyright © 2017 Black, Potter, Corbett, Clark and Draper. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.


  • ˙VO2
  • ˙VO2 kinetics
  • Severe intensity
  • Hypoxia
  • Treadmill running


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