Mathematical analysis of a model for HIV-malaria co-infection

Zindoga Mukandavire, Abba B Gumel, Winston Garira, Jean Michel Tchuenche

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

A deterministic model for the co-interaction of HIV and malaria in a community is presented and rigorously analyzed. Two sub-models, namely the HIV-only and malaria-only sub-models, are considered first of all. Unlike the HIV-only sub-model, which has a globally-asymptotically stable disease-free equilibrium whenever the associated reproduction number is less than unity, the malaria-only sub-model undergoes the phenomenon of backward bifurcation, where a stable disease-free equilibrium co-exists with a stable endemic equilibrium, for a certain range of the associated reproduction number less than unity. Thus, for malaria, the classical requirement of having the associated reproduction number to be less than unity, although necessary, is not sufficient for its elimination. It is also shown, using centre manifold theory, that the full HIV-malaria co-infection model undergoes backward bifurcation. Simulations of the full HIV-malaria model show that the two diseases co-exist whenever their reproduction numbers exceed unity (with no competitive exclusion occurring). Further, the reduction in sexual activity of individuals with malaria symptoms decreases the number of new cases of HIV and the mixed HIV-malaria infection while increasing the number of malaria cases. Finally, these simulations show that the HIV-induced increase in susceptibility to malaria infection has marginal effect on the new cases of HIV and malaria but increases the number of new cases of the dual HIV-malaria infection.

Original languageEnglish
Pages (from-to)333-362
Number of pages30
JournalMathematical Biosciences and Engineering
Volume6
Issue number2
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

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Coinfection
Malaria
HIV
Reproduction
HIV Infections
Sexual Behavior

Keywords

  • Biometry
  • Comorbidity
  • Computer Simulation
  • Disease Outbreaks
  • HIV Infections
  • Humans
  • Malaria
  • Models, Biological
  • Prevalence
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Mathematical analysis of a model for HIV-malaria co-infection. / Mukandavire, Zindoga; Gumel, Abba B; Garira, Winston; Tchuenche, Jean Michel.

In: Mathematical Biosciences and Engineering, Vol. 6, No. 2, 04.2009, p. 333-362.

Research output: Contribution to journalArticle

Mukandavire, Zindoga ; Gumel, Abba B ; Garira, Winston ; Tchuenche, Jean Michel. / Mathematical analysis of a model for HIV-malaria co-infection. In: Mathematical Biosciences and Engineering. 2009 ; Vol. 6, No. 2. pp. 333-362.
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