Maternal metabolic adaptations are necessary for normal offspring growth and brain development

Angela M Ramos-Lobo, Isadora C Furigo, Pryscila D S Teixeira, Thais T Zampieri, Frederick Wasinski, Daniella C Buonfiglio, Jose Donato

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
13 Downloads (Pure)

Abstract

Several metabolic adaptations emerge during pregnancy and continue through lactation, including increases in food intake and body weight, as well as insulin and leptin resistance. These maternal adaptations are thought to play a role in offspring viability and success. Using a model of attenuated maternal metabolic adaptations induced by ablation of the Socs3 gene in leptin receptor expressing cells (SOCS3 KO mice), our study aimed to investigate whether maternal metabolic changes are required for normal offspring development, and if their absence causes metabolic imbalances in adulthood. The litters were subjected to a cross-fostering experimental design to distinguish the prenatal and postnatal effects caused by maternal metabolic adaptations. Males either born or raised by SOCS3 KO mice showed reduced body weight until 8 weeks of life. Both adult males and females born or raised by SOCS3 KO mice also had lower body adiposity. Despite that, no significant changes in energy expenditure, glucose tolerance or insulin resistance were observed. However, males either born or raised by SOCS3 KO mice showed reduced brain mass in adulthood. Furthermore, animals born from SOCS3 KO mice also had lower proopiomelanocortin fiber density in the paraventricular nucleus of the hypothalamus. In conclusion, these findings indicate that the commonly observed metabolic changes in pregnancy and lactation are necessary for normal offspring growth and brain development.

Original languageEnglish
Article numbere13643
Number of pages15
JournalPhysiological Reports
Volume6
Issue number5
DOIs
Publication statusPublished - 13 Mar 2018
Externally publishedYes

Bibliographical note

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Keywords

  • Energy balance
  • Glucose homeostasis
  • Hypothalamus
  • Metabolic programming

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