MARK-AGE biomarkers of ageing

Alexander Bürkle; María Moreno-Villanueva; Jürgen Bernhard; María Blasco; Gerben Zondag; Jan H.J. Hoeijmakers; Olivier Toussaint; Beatrix Grubeck-Loebenstein; Eugenio Mocchegiani; Sebastiano Collino; Efstathios S. Gonos; Ewa Sikora; Daniela Gradinaru; Martijn Dollé; Michel Salmon; Peter Kristensen; Helen R. Griffiths; Claude Libert; Tilman Grune; Nicolle Breusing; Andreas Simm; Claudio Franceschi; Miriam Capri; Duncan Talbot; Paola Caiafa; Bertrand Friguet; P. Eline Slagboom; Antti Hervonen; Mikko Hurme; Richard Aspinall

doi:10.1016/j.mad.2015.03.006

MARK-AGE biomarkers of ageing

Alexander Bürkle
, María Moreno-Villanueva
, Jürgen Bernhard
, María Blasco
, Gerben Zondag
, Jan H.J. Hoeijmakers
, Olivier Toussaint
, Beatrix Grubeck-Loebenstein
, Eugenio Mocchegiani
, Sebastiano Collino
, Efstathios S. Gonos
, Ewa Sikora
, Daniela Gradinaru
, Martijn Dollé
, Michel Salmon
, Peter Kristensen
, Helen R. Griffiths
, Claude Libert
, Tilman Grune
, Nicolle Breusing

Andreas Simm, Claudio Franceschi, Miriam Capri, Duncan Talbot, Paola Caiafa, Bertrand Friguet, P. Eline Slagboom, Antti Hervonen, Mikko Hurme, Richard Aspinall

University of Konstanz
BioTeSys GmbH
Spanish National Cancer Research Centre (CNIO)
DNage BV
Erasmus University Medical Center
University of Namur
University of Innsbruck
INRCA
Ecole Polytechnique Fédérale de Lausanne
National Hellenic Research Foundation
Nencki Institute of Experimental Biology of the Polish Academy of Sciences
Ana Aslan - National Institute of Gerontology and Geriatrics
National Institute for Public Health and the Environment
Straticell
Aarhus University
Aston University
VIB
University of Hohenheim
University of Jena
University Hospital Halle
Universita di Bologna
Unilever
Sapienza University of Rome
INSERM
Leiden University
University of Tampere
Cranfield University

Research output: Contribution to journal › Article › peer-review

194 Citations (Scopus)

58 Downloads (Pure)

Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Original language	English
Pages (from-to)	2-12
Number of pages	11
Journal	Mechanisms of Ageing and Development
Volume	151
Early online date	24 Mar 2015
DOIs	https://doi.org/10.1016/j.mad.2015.03.006
Publication status	Published - 1 Nov 2015
Externally published	Yes

Bibliographical note

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

Funding

We wish to thank the European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880 ). We are very grateful to Dr. Beatrice Lucaroni (European Commission Scientific Officer in charge of the MARK-AGE project) for her excellent support and advice during all phases of the project.

Keywords

Ageing biomarkers
Human studies
MARK-AGE

ASJC Scopus subject areas

Ageing
Developmental Biology

Access to Document

10.1016/j.mad.2015.03.006Licence: CC BY-NC-ND

PublishedFinal published version, 1.15 MBLicence: CC BY-NC-ND

Cite this

Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., ... Aspinall, R. (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151, 2-12. https://doi.org/10.1016/j.mad.2015.03.006

Bürkle, A, Moreno-Villanueva, M, Bernhard, J, Blasco, M, Zondag, G, Hoeijmakers, JHJ, Toussaint, O, Grubeck-Loebenstein, B, Mocchegiani, E, Collino, S, Gonos, ES, Sikora, E, Gradinaru, D, Dollé, M, Salmon, M, Kristensen, P, Griffiths, HR, Libert, C, Grune, T, Breusing, N, Simm, A, Franceschi, C, Capri, M, Talbot, D, Caiafa, P, Friguet, B, Slagboom, PE, Hervonen, A, Hurme, M & Aspinall, R 2015, 'MARK-AGE biomarkers of ageing', Mechanisms of Ageing and Development, vol. 151, pp. 2-12. https://doi.org/10.1016/j.mad.2015.03.006

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abstract = "Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.",

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MARK-AGE biomarkers of ageing

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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