MARK-AGE biomarkers of ageing

Alexander Bürkle; María Moreno-Villanueva; Jürgen Bernhard; María Blasco; Gerben Zondag; Jan H.J. Hoeijmakers; Olivier Toussaint; Beatrix Grubeck-Loebenstein; Eugenio Mocchegiani; Sebastiano Collino; Efstathios S. Gonos; Ewa Sikora; Daniela Gradinaru; Martijn Dollé; Michel Salmon; Peter Kristensen; Helen R. Griffiths; Claude Libert; Tilman Grune; Nicolle Breusing; Andreas Simm; Claudio Franceschi; Miriam Capri; Duncan Talbot; Paola Caiafa; Bertrand Friguet; P. Eline Slagboom; Antti Hervonen; Mikko Hurme; Richard Aspinall

doi:10.1016/j.mad.2015.03.006

MARK-AGE biomarkers of ageing

Alexander Bürkle
, María Moreno-Villanueva
, Jürgen Bernhard
, María Blasco
, Gerben Zondag
, Jan H.J. Hoeijmakers
, Olivier Toussaint
, Beatrix Grubeck-Loebenstein
, Eugenio Mocchegiani
, Sebastiano Collino
, Efstathios S. Gonos
, Ewa Sikora
, Daniela Gradinaru
, Martijn Dollé
, Michel Salmon
, Peter Kristensen
, Helen R. Griffiths
, Claude Libert
, Tilman Grune
, Nicolle Breusing

Andreas Simm, Claudio Franceschi, Miriam Capri, Duncan Talbot, Paola Caiafa, Bertrand Friguet, P. Eline Slagboom, Antti Hervonen, Mikko Hurme, Richard Aspinall

Research output: Contribution to journal › Article › peer-review

191 Citations (Scopus)

55 Downloads (Pure)

Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Original language	English
Pages (from-to)	2-12
Number of pages	11
Journal	Mechanisms of Ageing and Development
Volume	151
Early online date	24 Mar 2015
DOIs	https://doi.org/10.1016/j.mad.2015.03.006
Publication status	Published - 1 Nov 2015
Externally published	Yes

Bibliographical note

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

Funding

We wish to thank the European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880 ). We are very grateful to Dr. Beatrice Lucaroni (European Commission Scientific Officer in charge of the MARK-AGE project) for her excellent support and advice during all phases of the project.

Keywords

Ageing biomarkers
Human studies
MARK-AGE

ASJC Scopus subject areas

Ageing
Developmental Biology

Access to Document

10.1016/j.mad.2015.03.006Licence: CC BY-NC-ND

PublishedFinal published version, 1.15 MBLicence: CC BY-NC-ND

Cite this

Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., ... Aspinall, R. (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151, 2-12. https://doi.org/10.1016/j.mad.2015.03.006

Bürkle, A, Moreno-Villanueva, M, Bernhard, J, Blasco, M, Zondag, G, Hoeijmakers, JHJ, Toussaint, O, Grubeck-Loebenstein, B, Mocchegiani, E, Collino, S, Gonos, ES, Sikora, E, Gradinaru, D, Dollé, M, Salmon, M, Kristensen, P, Griffiths, HR, Libert, C, Grune, T, Breusing, N, Simm, A, Franceschi, C, Capri, M, Talbot, D, Caiafa, P, Friguet, B, Slagboom, PE, Hervonen, A, Hurme, M & Aspinall, R 2015, 'MARK-AGE biomarkers of ageing', Mechanisms of Ageing and Development, vol. 151, pp. 2-12. https://doi.org/10.1016/j.mad.2015.03.006

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abstract = "Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.",

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AU - Talbot, Duncan

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AU - Friguet, Bertrand

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AU - Hervonen, Antti

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MARK-AGE biomarkers of ageing

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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