MARK-AGE biomarkers of ageing

Alexander Bürkle, María Moreno-Villanueva, Jürgen Bernhard, María Blasco, Gerben Zondag, Jan H.J. Hoeijmakers, Olivier Toussaint, Beatrix Grubeck-Loebenstein, Eugenio Mocchegiani, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Martijn Dollé, Michel Salmon, Peter Kristensen, Helen R. Griffiths, Claude Libert, Tilman Grune, Nicolle Breusing & 10 others Andreas Simm, Claudio Franceschi, Miriam Capri, Duncan Talbot, Paola Caiafa, Bertrand Friguet, P. Eline Slagboom, Antti Hervonen, Mikko Hurme, Richard Aspinall

Research output: Contribution to journalArticle

78 Citations (Scopus)
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Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Original languageEnglish
Pages (from-to)2-12
Number of pages11
JournalMechanisms of Ageing and Development
Volume151
Early online date24 Mar 2015
DOIs
Publication statusPublished - 1 Nov 2015
Externally publishedYes

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Biomarkers
Literature
Cross-Sectional Studies
Population

Bibliographical note

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

Keywords

  • Ageing biomarkers
  • Human studies
  • MARK-AGE

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

Cite this

Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., ... Aspinall, R. (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151, 2-12. https://doi.org/10.1016/j.mad.2015.03.006

MARK-AGE biomarkers of ageing. / Bürkle, Alexander; Moreno-Villanueva, María; Bernhard, Jürgen; Blasco, María; Zondag, Gerben; Hoeijmakers, Jan H.J.; Toussaint, Olivier; Grubeck-Loebenstein, Beatrix; Mocchegiani, Eugenio; Collino, Sebastiano; Gonos, Efstathios S.; Sikora, Ewa; Gradinaru, Daniela; Dollé, Martijn; Salmon, Michel; Kristensen, Peter; Griffiths, Helen R.; Libert, Claude; Grune, Tilman; Breusing, Nicolle; Simm, Andreas; Franceschi, Claudio; Capri, Miriam; Talbot, Duncan; Caiafa, Paola; Friguet, Bertrand; Slagboom, P. Eline; Hervonen, Antti; Hurme, Mikko; Aspinall, Richard.

In: Mechanisms of Ageing and Development, Vol. 151, 01.11.2015, p. 2-12.

Research output: Contribution to journalArticle

Bürkle, A, Moreno-Villanueva, M, Bernhard, J, Blasco, M, Zondag, G, Hoeijmakers, JHJ, Toussaint, O, Grubeck-Loebenstein, B, Mocchegiani, E, Collino, S, Gonos, ES, Sikora, E, Gradinaru, D, Dollé, M, Salmon, M, Kristensen, P, Griffiths, HR, Libert, C, Grune, T, Breusing, N, Simm, A, Franceschi, C, Capri, M, Talbot, D, Caiafa, P, Friguet, B, Slagboom, PE, Hervonen, A, Hurme, M & Aspinall, R 2015, 'MARK-AGE biomarkers of ageing' Mechanisms of Ageing and Development, vol. 151, pp. 2-12. https://doi.org/10.1016/j.mad.2015.03.006
Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JHJ et al. MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development. 2015 Nov 1;151:2-12. https://doi.org/10.1016/j.mad.2015.03.006
Bürkle, Alexander ; Moreno-Villanueva, María ; Bernhard, Jürgen ; Blasco, María ; Zondag, Gerben ; Hoeijmakers, Jan H.J. ; Toussaint, Olivier ; Grubeck-Loebenstein, Beatrix ; Mocchegiani, Eugenio ; Collino, Sebastiano ; Gonos, Efstathios S. ; Sikora, Ewa ; Gradinaru, Daniela ; Dollé, Martijn ; Salmon, Michel ; Kristensen, Peter ; Griffiths, Helen R. ; Libert, Claude ; Grune, Tilman ; Breusing, Nicolle ; Simm, Andreas ; Franceschi, Claudio ; Capri, Miriam ; Talbot, Duncan ; Caiafa, Paola ; Friguet, Bertrand ; Slagboom, P. Eline ; Hervonen, Antti ; Hurme, Mikko ; Aspinall, Richard. / MARK-AGE biomarkers of ageing. In: Mechanisms of Ageing and Development. 2015 ; Vol. 151. pp. 2-12.
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