Magnesium intake and colorectal tumor risk: A case-control study and meta-analysis

Petra A. Wark, Rosa Lau, Teresa Norat, Ellen Kampman

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    Background: Dietary magnesium might be related to colorectal tumor risk through the pivotal roles of magnesium in cellular metabolism, insulin resistance, and systemic inflammation.

    Objective: We evaluated the hypothesis of whether higher dietary magnesium intake is associated with reduced colorectal tumor risk.

    Design: A case-control study on colorectal adenomas (768 cases; 709 polyp-free control subjects) and a meta-analysis of colorectal adenomas (3 case-control studies) and carcinomas (6 prospective cohort studies) were conducted. Dietary magnesium was estimated from food-frequency questionnaires in the case-control study and most studies in the meta-analyses. Data analysis comprised multiple logistic regression analysis (case-control study) and fixed- and random-effects meta-analyses.

    Results: The case-control study showed a nonsignificant inverse association between dietary magnesium intake and risk of colorectal adenomas (OR for every 100-mg/d increase: 0.81; 95% CI: 0.62, 1.06). However, inverse associations were observed only in subjects with BMI (in kg/m2) ≥25, in subjects aged ≥55 y, and for advanced adenomas. Associations did not vary by the calcium-to-magnesium intake ratio. In the meta-analysis, every 100-mg/d increase in magnesium intake was associated with 13% lower risk of colorectal adenomas (OR: 0.87; 95% CI: 0.75, 1.00) and 12% lower risk of colorectal cancer (RR: 0.88; 95% CI: 0.81, 0.97).

    Conclusions: Our findings support the hypothesis that higher intakes of dietary magnesium are associated with lower risk of colorectal tumors. The consumption of magnesium-rich foods may be a new avenue to explore further in the search for cancer-prevention strategies.

    Original languageEnglish
    Pages (from-to)622-631
    Number of pages10
    JournalAmerican Journal of Clinical Nutrition
    Volume96
    Issue number3
    DOIs
    Publication statusPublished - 1 Sep 2012

    Fingerprint

    Magnesium
    Meta-Analysis
    Case-Control Studies
    Colorectal Neoplasms
    Adenoma
    Food
    Polyps
    Insulin Resistance
    Cohort Studies
    Logistic Models
    Regression Analysis
    Prospective Studies
    Inflammation
    Calcium
    Carcinoma
    Neoplasms

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

    Cite this

    Magnesium intake and colorectal tumor risk : A case-control study and meta-analysis. / Wark, Petra A.; Lau, Rosa; Norat, Teresa; Kampman, Ellen.

    In: American Journal of Clinical Nutrition, Vol. 96, No. 3, 01.09.2012, p. 622-631.

    Research output: Contribution to journalArticle

    Wark, Petra A. ; Lau, Rosa ; Norat, Teresa ; Kampman, Ellen. / Magnesium intake and colorectal tumor risk : A case-control study and meta-analysis. In: American Journal of Clinical Nutrition. 2012 ; Vol. 96, No. 3. pp. 622-631.
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    abstract = "Background: Dietary magnesium might be related to colorectal tumor risk through the pivotal roles of magnesium in cellular metabolism, insulin resistance, and systemic inflammation.Objective: We evaluated the hypothesis of whether higher dietary magnesium intake is associated with reduced colorectal tumor risk.Design: A case-control study on colorectal adenomas (768 cases; 709 polyp-free control subjects) and a meta-analysis of colorectal adenomas (3 case-control studies) and carcinomas (6 prospective cohort studies) were conducted. Dietary magnesium was estimated from food-frequency questionnaires in the case-control study and most studies in the meta-analyses. Data analysis comprised multiple logistic regression analysis (case-control study) and fixed- and random-effects meta-analyses.Results: The case-control study showed a nonsignificant inverse association between dietary magnesium intake and risk of colorectal adenomas (OR for every 100-mg/d increase: 0.81; 95{\%} CI: 0.62, 1.06). However, inverse associations were observed only in subjects with BMI (in kg/m2) ≥25, in subjects aged ≥55 y, and for advanced adenomas. Associations did not vary by the calcium-to-magnesium intake ratio. In the meta-analysis, every 100-mg/d increase in magnesium intake was associated with 13{\%} lower risk of colorectal adenomas (OR: 0.87; 95{\%} CI: 0.75, 1.00) and 12{\%} lower risk of colorectal cancer (RR: 0.88; 95{\%} CI: 0.81, 0.97).Conclusions: Our findings support the hypothesis that higher intakes of dietary magnesium are associated with lower risk of colorectal tumors. The consumption of magnesium-rich foods may be a new avenue to explore further in the search for cancer-prevention strategies.",
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