Lymphoid tumours and breast cancer in ataxia telangiectasia: substantial protective effect of residual ATM kinase activity against childhood tumours

A Reiman, V Srinivasan, G Barone, J I Last, L L Wootton, E G Davies, M M Verhagen, M A Willemsen, C M Weemaes, P J Byrd, L Izatt, D F Easton, D J Thompson, A M Taylor

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

BACKGROUND: Immunodeficiency in ataxia telangiectasia (A-T) is less severe in patients expressing some mutant or normal ATM kinase activity. We, therefore, determined whether expression of residual ATM kinase activity also protected against tumour development in A-T.

METHODS: From a total of 296 consecutive genetically confirmed A-T patients from the British Isles and the Netherlands, we identified 66 patients who developed a malignant tumour; 47 lymphoid tumours and 19 non-lymphoid tumours were diagnosed. We determined their ATM mutations, and whether cells from these patients expressed any ATM with residual ATM kinase activity.

RESULTS: In childhood, total absence of ATM kinase activity was associated, almost exclusively, with development of lymphoid tumours. There was an overwhelming preponderance of tumours in patients <16 years without kinase activity compared with those with some residual activity, consistent with a substantial protective effect of residual ATM kinase activity against tumour development in childhood. In addition, the presence of eight breast cancers in A-T patients, a 30-fold increased risk, establishes breast cancer as part of the A-T phenotype.

CONCLUSION: Overall, a spectrum of tumour types is associated with A-T, consistent with involvement of ATM in different mechanisms of tumour formation. Tumour type was influenced by ATM allelic heterogeneity, residual ATM kinase activity and age.

Original languageEnglish
Pages (from-to)586-591
Number of pages6
JournalBritish Journal of Cancer
Volume105
Issue number4
DOIs
Publication statusPublished - 9 Aug 2011

Keywords

  • Adolescent
  • Adult
  • Ataxia Telangiectasia
  • Ataxia Telangiectasia Mutated Proteins
  • Brain Neoplasms
  • Breast Neoplasms
  • Cell Cycle Proteins
  • Child
  • DNA-Binding Proteins
  • Female
  • Humans
  • Immunoblotting
  • Kaplan-Meier Estimate
  • Lymphoma
  • Male
  • Mutation
  • Neoplasms
  • Netherlands
  • Protein-Serine-Threonine Kinases
  • Tumor Suppressor Proteins
  • United Kingdom
  • Young Adult
  • Journal Article
  • Research Support, Non-U.S. Gov't

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