Localization and structure of the muscarinic receptor ligand binding site

E. C. Hulme, C. A.M. Curtis, M. Wheatly, A. Aitken, A. C. Harris

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


A conserved aspartic acid residue in transmembrane helix 3 of the muscarinic acetylcholine receptors is important in binding the headgroup of muscarinic ligands. This acidic amino acid probably points into a relatively hydrophilic cavity whose walls are formed by the amphipathic transmembrane helices of the receptor. Amino acid side chains within this cavity contribute to ligand binding.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalTrends in Pharmacological Sciences
Issue numberSUPPL.
Publication statusPublished - 1 Dec 1989
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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