Abstract
Background: A limited number of studies have investigated the effects of lifestyle interventions in hypertrophic cardiomyopathy (HCM). This study evaluated the effect of a novel lifestyle intervention incorporating physical activity (PA) and dietary nitrate supplementation on heart rate variability (HRV) and haemodynamic measures in HCM.
Methods: Twenty-eight individuals with HCM were randomised into either the intervention or control group. Frequency-domain HRV measures including low frequency power (LF), high frequency power (HF) and LF/HF were recorded at rest using bioimpedance. Non-invasive haemodynamic variables were recorded at rest using bioreactance. Participants in the intervention group consumed 6 mmol of nitrate daily (concentrated beetroot juice) and were instructed to increase and maintain daily PA by ≥ 2000 steps/day above baseline for 16 weeks. Control group participants retained their usual lifestyle and monitored daily step counts.
Results: There was a significant increase in post-intervention HF power (7.54 ± 2.14 vs 8.78 ± 1.60 ms2, P <.01) and LF power (6.89 ± 2.33 vs 8.17 ± 1.55, P <.01) in the intervention but not in the control group. Resting mean arterial blood pressure (MABP) in the intervention group significantly reduced at follow-up (108 ± 6 vs 102 ± 7 mmHg, P <.01).
Conclusions: A novel lifestyle intervention including PA and dietary nitrate supplementation enhanced parasympathetic activity and resting MABP in HCM.
Methods: Twenty-eight individuals with HCM were randomised into either the intervention or control group. Frequency-domain HRV measures including low frequency power (LF), high frequency power (HF) and LF/HF were recorded at rest using bioimpedance. Non-invasive haemodynamic variables were recorded at rest using bioreactance. Participants in the intervention group consumed 6 mmol of nitrate daily (concentrated beetroot juice) and were instructed to increase and maintain daily PA by ≥ 2000 steps/day above baseline for 16 weeks. Control group participants retained their usual lifestyle and monitored daily step counts.
Results: There was a significant increase in post-intervention HF power (7.54 ± 2.14 vs 8.78 ± 1.60 ms2, P <.01) and LF power (6.89 ± 2.33 vs 8.17 ± 1.55, P <.01) in the intervention but not in the control group. Resting mean arterial blood pressure (MABP) in the intervention group significantly reduced at follow-up (108 ± 6 vs 102 ± 7 mmHg, P <.01).
Conclusions: A novel lifestyle intervention including PA and dietary nitrate supplementation enhanced parasympathetic activity and resting MABP in HCM.
| Original language | English |
|---|---|
| Pages (from-to) | (In-Press) |
| Number of pages | 12 |
| Journal | American Journal of Lifestyle Medicine |
| Volume | (In-Press) |
| Early online date | 16 May 2024 |
| DOIs | |
| Publication status | E-pub ahead of print - 16 May 2024 |
Bibliographical note
Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.
Funder
This project received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement no. 777204. Miss AI. Alyahya is supported by the Saudi Arabia Government and Imam Abdulrahman Bin Faisal University via an international doctoral scholarship. The views expressed are those of the authors. The funders of the study had no role in study design or in data collection, analysis, or interpretation.Keywords
- hypertrophic cardiomyopathy
- nitrate
- lifestyle
- haemodynamic function
- heart rate variability
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Health Policy
- Public Health, Environmental and Occupational Health
