Layer-specific strain in hypertensive patients with and without mild diastolic dysfunction

Hisham Sharif, Stephen Ting, Lynsey Forsythe, Gordon McGregor, Prithwish Banerjee, Deborah O'Leary, Davis Ditor, Keith George, Daniel Zehnder, Davis Oxborough

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    Abstract

    This study sought to examine layer-specific longitudinal and circumferential systolic and diastolic strain, strain rate (SR) and diastolic time intervals in hypertensive patients with and without diastolic dysfunction. Fifty-eight treated hypertensive patients were assigned to normal diastolic function (NDF, N=39) or mild diastolic dysfunction (DD, N=19) group. Layer-specific systolic and diastolic longitudinal and circumferential strains and SR were assessed. Results showed no between group difference in left ventricular mass index (DD: 92.1±18.1 vs NDF: 88.4±16.3; p=0.44). Patients with DD had a proportional reduction in longitudinal strain across the myocardium (endocardial for DD -13±4%; vs NDF -17±3, p<0.01; epicardial for DD -10±3% vs NDF -13±3%, p<0.01; global for DD: -12±3% vs NDF: -15±3, p=0.01), and longitudinal mechanical diastolic impairments as evidenced by reduced longitudinal strain rate of early diastole (DD 0.7±0.2 l/s vs NDF 1.0±0.3 l/s, p<0.01) and absence of a transmural gradient in the duration of diastolic strain (DD endocardial: 547±105ms vs epicardial: 542±113ms, p=0.24; NDF endocardial: 566±86ms vs epicardial: 553±77ms, p=0.03). Patients with DD also demonstrate a longer duration of early circumferential diastolic strain (231±71ms vs 189±58ms, p=0.02). In conclusion, hhypertensive patients with mild DD demonstrate a proportional reduction in longitudinal strain across the myocardium, as well as longitudinal mechanical diastolic impairment, and prolonging duration of circumferential mechanical relaxation.

    Original languageEnglish
    Pages (from-to)41-49
    Number of pages9
    JournalEcho Research and Practice
    Volume5
    Issue number1
    Early online date5 Feb 2018
    DOIs
    Publication statusPublished - 1 Mar 2018

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    Myocardium
    Diastole

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    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

    Keywords

    • diastolic dysfunction
    • hypertension
    • transmural gradient
    • layer-specific strain

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    Layer-specific strain in hypertensive patients with and without mild diastolic dysfunction. / Sharif, Hisham; Ting, Stephen; Forsythe, Lynsey; McGregor, Gordon; Banerjee, Prithwish; O'Leary, Deborah; Ditor, Davis; George, Keith; Zehnder, Daniel; Oxborough, Davis.

    In: Echo Research and Practice, Vol. 5, No. 1, 01.03.2018, p. 41-49.

    Research output: Contribution to journalArticle

    Sharif, H, Ting, S, Forsythe, L, McGregor, G, Banerjee, P, O'Leary, D, Ditor, D, George, K, Zehnder, D & Oxborough, D 2018, 'Layer-specific strain in hypertensive patients with and without mild diastolic dysfunction' Echo Research and Practice, vol. 5, no. 1, pp. 41-49. https://doi.org/10.1530/ERP-17-0072
    Sharif, Hisham ; Ting, Stephen ; Forsythe, Lynsey ; McGregor, Gordon ; Banerjee, Prithwish ; O'Leary, Deborah ; Ditor, Davis ; George, Keith ; Zehnder, Daniel ; Oxborough, Davis. / Layer-specific strain in hypertensive patients with and without mild diastolic dysfunction. In: Echo Research and Practice. 2018 ; Vol. 5, No. 1. pp. 41-49.
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    abstract = "This study sought to examine layer-specific longitudinal and circumferential systolic and diastolic strain, strain rate (SR) and diastolic time intervals in hypertensive patients with and without diastolic dysfunction. Fifty-eight treated hypertensive patients were assigned to normal diastolic function (NDF, N=39) or mild diastolic dysfunction (DD, N=19) group. Layer-specific systolic and diastolic longitudinal and circumferential strains and SR were assessed. Results showed no between group difference in left ventricular mass index (DD: 92.1±18.1 vs NDF: 88.4±16.3; p=0.44). Patients with DD had a proportional reduction in longitudinal strain across the myocardium (endocardial for DD -13±4{\%}; vs NDF -17±3, p<0.01; epicardial for DD -10±3{\%} vs NDF -13±3{\%}, p<0.01; global for DD: -12±3{\%} vs NDF: -15±3, p=0.01), and longitudinal mechanical diastolic impairments as evidenced by reduced longitudinal strain rate of early diastole (DD 0.7±0.2 l/s vs NDF 1.0±0.3 l/s, p<0.01) and absence of a transmural gradient in the duration of diastolic strain (DD endocardial: 547±105ms vs epicardial: 542±113ms, p=0.24; NDF endocardial: 566±86ms vs epicardial: 553±77ms, p=0.03). Patients with DD also demonstrate a longer duration of early circumferential diastolic strain (231±71ms vs 189±58ms, p=0.02). In conclusion, hhypertensive patients with mild DD demonstrate a proportional reduction in longitudinal strain across the myocardium, as well as longitudinal mechanical diastolic impairment, and prolonging duration of circumferential mechanical relaxation.",
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    T1 - Layer-specific strain in hypertensive patients with and without mild diastolic dysfunction

    AU - Sharif, Hisham

    AU - Ting, Stephen

    AU - Forsythe, Lynsey

    AU - McGregor, Gordon

    AU - Banerjee, Prithwish

    AU - O'Leary, Deborah

    AU - Ditor, Davis

    AU - George, Keith

    AU - Zehnder, Daniel

    AU - Oxborough, Davis

    N1 - This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

    PY - 2018/3/1

    Y1 - 2018/3/1

    N2 - This study sought to examine layer-specific longitudinal and circumferential systolic and diastolic strain, strain rate (SR) and diastolic time intervals in hypertensive patients with and without diastolic dysfunction. Fifty-eight treated hypertensive patients were assigned to normal diastolic function (NDF, N=39) or mild diastolic dysfunction (DD, N=19) group. Layer-specific systolic and diastolic longitudinal and circumferential strains and SR were assessed. Results showed no between group difference in left ventricular mass index (DD: 92.1±18.1 vs NDF: 88.4±16.3; p=0.44). Patients with DD had a proportional reduction in longitudinal strain across the myocardium (endocardial for DD -13±4%; vs NDF -17±3, p<0.01; epicardial for DD -10±3% vs NDF -13±3%, p<0.01; global for DD: -12±3% vs NDF: -15±3, p=0.01), and longitudinal mechanical diastolic impairments as evidenced by reduced longitudinal strain rate of early diastole (DD 0.7±0.2 l/s vs NDF 1.0±0.3 l/s, p<0.01) and absence of a transmural gradient in the duration of diastolic strain (DD endocardial: 547±105ms vs epicardial: 542±113ms, p=0.24; NDF endocardial: 566±86ms vs epicardial: 553±77ms, p=0.03). Patients with DD also demonstrate a longer duration of early circumferential diastolic strain (231±71ms vs 189±58ms, p=0.02). In conclusion, hhypertensive patients with mild DD demonstrate a proportional reduction in longitudinal strain across the myocardium, as well as longitudinal mechanical diastolic impairment, and prolonging duration of circumferential mechanical relaxation.

    AB - This study sought to examine layer-specific longitudinal and circumferential systolic and diastolic strain, strain rate (SR) and diastolic time intervals in hypertensive patients with and without diastolic dysfunction. Fifty-eight treated hypertensive patients were assigned to normal diastolic function (NDF, N=39) or mild diastolic dysfunction (DD, N=19) group. Layer-specific systolic and diastolic longitudinal and circumferential strains and SR were assessed. Results showed no between group difference in left ventricular mass index (DD: 92.1±18.1 vs NDF: 88.4±16.3; p=0.44). Patients with DD had a proportional reduction in longitudinal strain across the myocardium (endocardial for DD -13±4%; vs NDF -17±3, p<0.01; epicardial for DD -10±3% vs NDF -13±3%, p<0.01; global for DD: -12±3% vs NDF: -15±3, p=0.01), and longitudinal mechanical diastolic impairments as evidenced by reduced longitudinal strain rate of early diastole (DD 0.7±0.2 l/s vs NDF 1.0±0.3 l/s, p<0.01) and absence of a transmural gradient in the duration of diastolic strain (DD endocardial: 547±105ms vs epicardial: 542±113ms, p=0.24; NDF endocardial: 566±86ms vs epicardial: 553±77ms, p=0.03). Patients with DD also demonstrate a longer duration of early circumferential diastolic strain (231±71ms vs 189±58ms, p=0.02). In conclusion, hhypertensive patients with mild DD demonstrate a proportional reduction in longitudinal strain across the myocardium, as well as longitudinal mechanical diastolic impairment, and prolonging duration of circumferential mechanical relaxation.

    KW - diastolic dysfunction

    KW - hypertension

    KW - transmural gradient

    KW - layer-specific strain

    U2 - 10.1530/ERP-17-0072

    DO - 10.1530/ERP-17-0072

    M3 - Article

    VL - 5

    SP - 41

    EP - 49

    JO - Echo Research and Practice

    JF - Echo Research and Practice

    SN - 2055-0464

    IS - 1

    ER -