Laser Surface Engineering of Polymeric Materials for Enhanced Mesenchymal Stem Cell Adhesion and Growth

David Waugh, Daniel Cosgrove, Issam Hussain, Jonathan Lawrence

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Owing to them being relatively inexpensive and easy to manipulate, polymers are becoming more widely used within the biomedical industry for several different applications. As an example, because of its high wear resistance, low moisture absorption and high chemical resistance, poly(ether ether ketone) is commonly used as a biomaterial in the healthcare and biomedical industries. However, poly(ether ether ketone) surface properties are not optimum for efficient or enhanced bio-functionality, leading it to have somewhat inferior wettability and adhesion characteristics. On account of this, many researchers are now looking to employ surface engineering techniques to improve and enhance the surface properties of poly(ether ether ketone), enhancing its biomimetic nature and improving the bio-adhesion properties. This chapter discusses the importance of Mesenchymal Stem Cells (MSCs), the biological applications of poly(ether ether ketone) and the application of lasers for surface engineering of poly(ether ether ketone) for modifying mesenchymal stem cell response. Through the application of CO2 laser surface engineering it has been shown that laser surface engineering can have a positive effect on the rate of human mesenchymal cell growth, highlighting the opportunities for the healthcare and biomedical industries to adopt such technique. In addition, discussion of including poly(ether ether ketone) and other polymer materials as bio-composite materials for future research is introduced for enhancing material properties.
Original languageEnglish
Title of host publicationContact Angle, Wettability and Adhesion
EditorsKash Mittal
Place of PublicationNew York
PublisherScrivener Publishing
Pages(In-press)
Volume4
Publication statusAccepted/In press - 3 May 2019

Fingerprint

Polyether ether ketones
Cell adhesion
Cell growth
Stem cells
Lasers
Polymers
Surface properties
Adhesion
Industry
Chemical resistance
Biomimetics
Biocompatible Materials
Wear resistance
Wetting
Materials properties
Moisture
Composite materials

Keywords

  • Mesenchymal Stem Cells
  • Poly(ether ether ketone)
  • Surface Modification
  • Bio-Engineering
  • Laser Treatment
  • Polymeric Biomaterials
  • Surface Engineering

Cite this

Waugh, D., Cosgrove, D., Hussain, I., & Lawrence, J. (Accepted/In press). Laser Surface Engineering of Polymeric Materials for Enhanced Mesenchymal Stem Cell Adhesion and Growth. In K. Mittal (Ed.), Contact Angle, Wettability and Adhesion (Vol. 4, pp. (In-press)). New York: Scrivener Publishing.

Laser Surface Engineering of Polymeric Materials for Enhanced Mesenchymal Stem Cell Adhesion and Growth. / Waugh, David; Cosgrove, Daniel; Hussain, Issam; Lawrence, Jonathan.

Contact Angle, Wettability and Adhesion. ed. / Kash Mittal. Vol. 4 New York : Scrivener Publishing, 2019. p. (In-press).

Research output: Chapter in Book/Report/Conference proceedingChapter

Waugh, D, Cosgrove, D, Hussain, I & Lawrence, J 2019, Laser Surface Engineering of Polymeric Materials for Enhanced Mesenchymal Stem Cell Adhesion and Growth. in K Mittal (ed.), Contact Angle, Wettability and Adhesion. vol. 4, Scrivener Publishing, New York, pp. (In-press).
Waugh D, Cosgrove D, Hussain I, Lawrence J. Laser Surface Engineering of Polymeric Materials for Enhanced Mesenchymal Stem Cell Adhesion and Growth. In Mittal K, editor, Contact Angle, Wettability and Adhesion. Vol. 4. New York: Scrivener Publishing. 2019. p. (In-press)
Waugh, David ; Cosgrove, Daniel ; Hussain, Issam ; Lawrence, Jonathan. / Laser Surface Engineering of Polymeric Materials for Enhanced Mesenchymal Stem Cell Adhesion and Growth. Contact Angle, Wettability and Adhesion. editor / Kash Mittal. Vol. 4 New York : Scrivener Publishing, 2019. pp. (In-press)
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AB - Owing to them being relatively inexpensive and easy to manipulate, polymers are becoming more widely used within the biomedical industry for several different applications. As an example, because of its high wear resistance, low moisture absorption and high chemical resistance, poly(ether ether ketone) is commonly used as a biomaterial in the healthcare and biomedical industries. However, poly(ether ether ketone) surface properties are not optimum for efficient or enhanced bio-functionality, leading it to have somewhat inferior wettability and adhesion characteristics. On account of this, many researchers are now looking to employ surface engineering techniques to improve and enhance the surface properties of poly(ether ether ketone), enhancing its biomimetic nature and improving the bio-adhesion properties. This chapter discusses the importance of Mesenchymal Stem Cells (MSCs), the biological applications of poly(ether ether ketone) and the application of lasers for surface engineering of poly(ether ether ketone) for modifying mesenchymal stem cell response. Through the application of CO2 laser surface engineering it has been shown that laser surface engineering can have a positive effect on the rate of human mesenchymal cell growth, highlighting the opportunities for the healthcare and biomedical industries to adopt such technique. In addition, discussion of including poly(ether ether ketone) and other polymer materials as bio-composite materials for future research is introduced for enhancing material properties.

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