Laser melting of NiTi and its effects on in vitro mesenchymal stem cell responses

D. G. Waugh, J. Lawrence, C. W. Chan, I. Hussain, H. C. Man

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Control of cell adhesion to synthetic polymers is a key factor in tissue engineering. The bioactivity of NiTi after laser melting was investigated implementing in vitro techniques for studying mesenchymal stem cell (MSC) responses. The effects of physical (surface roughness and topography) and chemical (surface Ti/Ni ratio) modifications as a consequence of laser melting on the cell morphology and cell coverage were studied. The results indicate that MSC morphology was affected primarily by topographical factors. No toxic effect in terms of Ni release affected the MSCs, as evidenced by the adhesion and spreading of the cells.

Original languageEnglish
Title of host publicationLaser Surface Engineering
Subtitle of host publicationProcesses and Applications
EditorsJ. Lawrence, D.G. Waugh
Place of PublicationSawston
PublisherWoodhead Publishing Limited
Pages653-676
Number of pages24
ISBN (Electronic)9781782420798
ISBN (Print)9781782420743
DOIs
Publication statusPublished - 10 Oct 2014
Externally publishedYes

Keywords

  • Fiber laser
  • Laser melting
  • Mesenchymal stem cell (MSC)
  • NiTi

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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  • Cite this

    Waugh, D. G., Lawrence, J., Chan, C. W., Hussain, I., & Man, H. C. (2014). Laser melting of NiTi and its effects on in vitro mesenchymal stem cell responses. In J. Lawrence, & D. G. Waugh (Eds.), Laser Surface Engineering: Processes and Applications (pp. 653-676). Sawston: Woodhead Publishing Limited. https://doi.org/10.1016/B978-1-78242-074-3.00027-1