Lactone synthesis activity in a site-directed mutant of an extradiol catechol dioxygenase enzyme

Sharon Mendel, Andrew Arndt, Timothy D H Bugg

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A H115Y site-directed mutant of extradiol catechol dioxygenase MhpB catalyses an intramolecular lactonisation reaction upon its natural substrate.

Original languageEnglish
Pages (from-to)666-668
Number of pages3
JournalChemical communications (Cambridge, England)
Issue number5
DOIs
Publication statusPublished - 7 Feb 2005

Keywords

  • Amino Acid Substitution
  • Catalysis
  • Dioxygenases
  • Escherichia coli
  • Lactones
  • Molecular Structure
  • Mutagenesis, Site-Directed
  • Oxygenases
  • Journal Article
  • Research Support, Non-U.S. Gov't

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