Lactone synthesis activity in a site-directed mutant of an extradiol catechol dioxygenase enzyme

Sharon Mendel; Andrew Arndt; Timothy D H Bugg

doi:10.1039/b414292f

Lactone synthesis activity in a site-directed mutant of an extradiol catechol dioxygenase enzyme

Sharon Mendel, Andrew Arndt, Timothy D H Bugg

School of Life Sciences

University of Warwick

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A H115Y site-directed mutant of extradiol catechol dioxygenase MhpB catalyses an intramolecular lactonisation reaction upon its natural substrate.

Original language	English
Pages (from-to)	666-668
Number of pages	3
Journal	Chemical communications (Cambridge, England)
Issue number	5
DOIs	https://doi.org/10.1039/b414292f
Publication status	Published - 7 Feb 2005

Keywords

Amino Acid Substitution
Catalysis
Dioxygenases
Escherichia coli
Lactones
Molecular Structure
Mutagenesis, Site-Directed
Oxygenases
Journal Article
Research Support, Non-U.S. Gov't

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10.1039/b414292f

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title = "Lactone synthesis activity in a site-directed mutant of an extradiol catechol dioxygenase enzyme",

abstract = "A H115Y site-directed mutant of extradiol catechol dioxygenase MhpB catalyses an intramolecular lactonisation reaction upon its natural substrate.",

keywords = "Amino Acid Substitution, Catalysis, Dioxygenases, Escherichia coli, Lactones, Molecular Structure, Mutagenesis, Site-Directed, Oxygenases, Journal Article, Research Support, Non-U.S. Gov't",

author = "Sharon Mendel and Andrew Arndt and Bugg, {Timothy D H}",

year = "2005",

month = feb,

day = "7",

doi = "10.1039/b414292f",

language = "English",

pages = "666--668",

journal = "Chemical communications (Cambridge, England)",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "5",

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T1 - Lactone synthesis activity in a site-directed mutant of an extradiol catechol dioxygenase enzyme

AU - Mendel, Sharon

AU - Arndt, Andrew

AU - Bugg, Timothy D H

PY - 2005/2/7

Y1 - 2005/2/7

N2 - A H115Y site-directed mutant of extradiol catechol dioxygenase MhpB catalyses an intramolecular lactonisation reaction upon its natural substrate.

AB - A H115Y site-directed mutant of extradiol catechol dioxygenase MhpB catalyses an intramolecular lactonisation reaction upon its natural substrate.

KW - Amino Acid Substitution

KW - Catalysis

KW - Dioxygenases

KW - Escherichia coli

KW - Lactones

KW - Molecular Structure

KW - Mutagenesis, Site-Directed

KW - Oxygenases

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1039/b414292f

DO - 10.1039/b414292f

M3 - Article

C2 - 15672171

SN - 1359-7345

SP - 666

EP - 668

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 5

ER -

Lactone synthesis activity in a site-directed mutant of an extradiol catechol dioxygenase enzyme

Abstract

Keywords

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