Lactoferrin - A multifunctional protein with antimicrobial properties

Sebastien Farnaud, Robert W. Evans

Research output: Contribution to journalReview article

478 Citations (Scopus)

Abstract

Lactoferrin is a member of the transferrin family of iron-binding proteins. Numerous functions have been reported and continue to be reported for the protein, some of which are related to its iron-binding properties. Its extensive antimicrobial activities were originally attributed to its ability to sequester essential iron, however, it is now established that it possesses bactericidal activities as a result of a direct interaction between the protein or lactoferrin-derived peptides. This article reviews the antimicrobial activities of lactoferrin and discusses the potential mode of action of lactoferrin-derived cationic peptides against Gram-negative bacteria in the light of recent studies.

Original languageEnglish
Pages (from-to)395-405
Number of pages11
JournalMolecular Immunology
Volume40
Issue number7
DOIs
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • Antimicrobials
  • Cationic peptides
  • Iron
  • Lactoferricin
  • Lactoferrin

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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