Abstract
Lactoferrin is a member of the transferrin family of iron-binding proteins. Numerous functions have been reported and continue to be reported for the protein, some of which are related to its iron-binding properties. Its extensive antimicrobial activities were originally attributed to its ability to sequester essential iron, however, it is now established that it possesses bactericidal activities as a result of a direct interaction between the protein or lactoferrin-derived peptides. This article reviews the antimicrobial activities of lactoferrin and discusses the potential mode of action of lactoferrin-derived cationic peptides against Gram-negative bacteria in the light of recent studies.
Original language | English |
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Pages (from-to) | 395-405 |
Number of pages | 11 |
Journal | Molecular Immunology |
Volume | 40 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2003 |
Externally published | Yes |
Keywords
- Antimicrobials
- Cationic peptides
- Iron
- Lactoferricin
- Lactoferrin
ASJC Scopus subject areas
- Immunology
- Molecular Biology