Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake

Fulvia Draicchio, Volker Behrends, Neale A. Tillin, Nicholas M. Hurren, Lykke Sylow, Richard Mackenzie

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)
3 Downloads (Pure)

Abstract

Whole-body euglycaemia is partly maintained by two cellular processes that encourage glucose uptake in skeletal muscle, the insulin- and contraction-stimulated pathways, with research suggesting convergence between these two processes. The normal structural integrity of the skeletal muscle requires an intact actin cytoskeleton as well as integrin-associated proteins, and thus those structures are likely fundamental for effective glucose uptake in skeletal muscle. In contrast, excessive extracellular matrix (ECM) remodelling and integrin expression in skeletal muscle may contribute to insulin resistance owing to an increased physical barrier causing reduced nutrient and hormonal flux. This review explores the role of the ECM and the actin cytoskeleton in insulin- and contraction-mediated glucose uptake in skeletal muscle. This is a clinically important area of research given that defects in the structural integrity of the ECM and integrin-associated proteins may contribute to loss of muscle function and decreased glucose uptake in type 2 diabetes.

Original languageEnglish
Pages (from-to)4393-4408
Number of pages16
JournalThe Journal of Physiology
Volume600
Issue number20
Early online date2 Sept 2022
DOIs
Publication statusPublished - 15 Oct 2022
Externally publishedYes

Bibliographical note

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Keywords

  • actin cytoskeleton
  • ECM
  • ILK
  • insulin
  • insulin resistance
  • integrin
  • muscle contraction
  • Rac1

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