Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images

Thanapong Chaichana, Zhonghua Sun, James Jewkes

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The aim of this study was to investigate the plaques at the left coronary artery (LCA) and their effect on the haemodynamic and wall shear stress (WSS) in realistic patient models. Three sample patients with left coronary disease were selected based on CT data. The plaques were present at the left anterior descending and left circumflex branches with more than 50 % lumen narrowing. Computational fluid dynamics analysis was used to perform simulation of patient-specific models with realistic physiological conditions that demonstrate in vivo cardiac flow. WSS and blood flow in the LCA were measured during cardiac cycles. Our results showed that WSS was found to increase at the stenotic locations and decrease at pre- and post-plaque locations, whilst the recirculation location was found at postplaque regions. There is a strong correlation between coronary bifurcation plaques and hemodynamic and WSS changes, based on the realistic coronary disease models.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalAustralasian Physical and Engineering Sciences in Medicine
Volume35
Issue number2
Early online date17 Apr 2012
DOIs
Publication statusPublished - Jun 2012
Externally publishedYes

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Hemodynamics
Coronary Disease
Shear stress
Coronary Vessels
Patient Simulation
Hydrodynamics
Dynamic analysis
Computational fluid dynamics
Blood

Keywords

  • Atherosclerosis
  • Computational fluid dynamics
  • Coronary artery disease
  • Haemodynamic
  • Plaques

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "The aim of this study was to investigate the plaques at the left coronary artery (LCA) and their effect on the haemodynamic and wall shear stress (WSS) in realistic patient models. Three sample patients with left coronary disease were selected based on CT data. The plaques were present at the left anterior descending and left circumflex branches with more than 50 {\%} lumen narrowing. Computational fluid dynamics analysis was used to perform simulation of patient-specific models with realistic physiological conditions that demonstrate in vivo cardiac flow. WSS and blood flow in the LCA were measured during cardiac cycles. Our results showed that WSS was found to increase at the stenotic locations and decrease at pre- and post-plaque locations, whilst the recirculation location was found at postplaque regions. There is a strong correlation between coronary bifurcation plaques and hemodynamic and WSS changes, based on the realistic coronary disease models.",
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AU - Chaichana, Thanapong

AU - Sun, Zhonghua

AU - Jewkes, James

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AB - The aim of this study was to investigate the plaques at the left coronary artery (LCA) and their effect on the haemodynamic and wall shear stress (WSS) in realistic patient models. Three sample patients with left coronary disease were selected based on CT data. The plaques were present at the left anterior descending and left circumflex branches with more than 50 % lumen narrowing. Computational fluid dynamics analysis was used to perform simulation of patient-specific models with realistic physiological conditions that demonstrate in vivo cardiac flow. WSS and blood flow in the LCA were measured during cardiac cycles. Our results showed that WSS was found to increase at the stenotic locations and decrease at pre- and post-plaque locations, whilst the recirculation location was found at postplaque regions. There is a strong correlation between coronary bifurcation plaques and hemodynamic and WSS changes, based on the realistic coronary disease models.

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KW - Computational fluid dynamics

KW - Coronary artery disease

KW - Haemodynamic

KW - Plaques

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