This study offers a novel evaluation of the conditions for Total Entrpreneurial Activity (TEA) and Entrepreneurial Intention (EI) across 59 Sub-Saharan African regions. The analysis employs fuzzy-set Qualitative Comparative Analysis using Global Entrepreneurship Monitor (2013) survey data using five condition variables, measuring regional-level entrepreneurial attitudes and perceptions, including education level, considered against TEA and EI. This novel regional contribution identifies diversity between African countries and regions for entrepreneurial actvities and its drivers, with several groups identified. This highlights a requirement for future research encompassing further countries and regions in African, and also multi-year studies that can track these issues longitudinally. The study informs knowledge and practice regarding entrepreneurial behaviour across African regions. Through examination of the different combinations of condition variables, across causal recipes, it provides understanding of variations in the socio-cultural drivers of entrepreneurial activity between regions, groups of regions, and countries, for TEA and EI.