Investigating the transmissibility of tet(W) in bifidobacteria exposed to acid and bile stress

Agnieszka Polit; Huiying Yang; Daniel Amund

doi:10.12938/bmfh.17-017

Investigating the transmissibility of tet(W) in bifidobacteria exposed to acid and bile stress

Agnieszka Polit, Huiying Yang, Daniel Amund

School of Life Sciences

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1 Citation (Scopus)

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Abstract

Transfer of antibiotic resistance genes from probiotic bacteria to pathogens poses a safety concern. Orally administered probiotics are exposed to stressful conditions during gastrointestinal transit. In this study, filter mating experiments were performed to investigate the potential role of exposure of Bifidobacterium isolates to acid and bile stress on the transfer of a tetracycline resistance gene, tet(W), to Enterococcus faecalis ATCC 51299. No E. faecalis transconjugants were obtained after mating with either stressed or unstressed Bifidobacterium, thereby suggesting that tet(W) could not be transferred as a result of exposure to gastrointestinal stresses.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	Bioscience of Microbiota, Food and Health
Volume	37
Issue number	2
Early online date	6 Jan 2018
DOIs	https://doi.org/10.12938/bmfh.17-017
Publication status	Published - 13 Apr 2018

Bibliographical note

This is an open-access article distributed under the terms of the Creative
Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
(CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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title = "Investigating the transmissibility of tet(W) in bifidobacteria exposed to acid and bile stress",

abstract = "Transfer of antibiotic resistance genes from probiotic bacteria to pathogens poses a safety concern. Orally administered probiotics are exposed to stressful conditions during gastrointestinal transit. In this study, filter mating experiments were performed to investigate the potential role of exposure of Bifidobacterium isolates to acid and bile stress on the transfer of a tetracycline resistance gene, tet(W), to Enterococcus faecalis ATCC 51299. No E. faecalis transconjugants were obtained after mating with either stressed or unstressed Bifidobacterium, thereby suggesting that tet(W) could not be transferred as a result of exposure to gastrointestinal stresses.",

author = "Agnieszka Polit and Huiying Yang and Daniel Amund",

note = "This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)",

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AB - Transfer of antibiotic resistance genes from probiotic bacteria to pathogens poses a safety concern. Orally administered probiotics are exposed to stressful conditions during gastrointestinal transit. In this study, filter mating experiments were performed to investigate the potential role of exposure of Bifidobacterium isolates to acid and bile stress on the transfer of a tetracycline resistance gene, tet(W), to Enterococcus faecalis ATCC 51299. No E. faecalis transconjugants were obtained after mating with either stressed or unstressed Bifidobacterium, thereby suggesting that tet(W) could not be transferred as a result of exposure to gastrointestinal stresses.

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