Investigating the transmissibility of tet(W) in bifidobacteria exposed to acid and bile stress

Agnieszka Polit, Huiying Yang, Daniel Amund

Research output: Contribution to journal › Article

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Abstract

Transfer of antibiotic resistance genes from probiotic bacteria to pathogens poses a safety concern. Orally administered probiotics are exposed to stressful conditions during gastrointestinal transit. In this study, filter mating experiments were performed to investigate the potential role of exposure of Bifidobacterium isolates to acid and bile stress on the transfer of a tetracycline resistance gene, tet(W), to Enterococcus faecalis ATCC 51299. No E. faecalis transconjugants were obtained after mating with either stressed or unstressed Bifidobacterium, thereby suggesting that tet(W) could not be transferred as a result of exposure to gastrointestinal stresses.
Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalBioscience of Microbiota, Food and Health
Volume37
Issue number2
Early online date6 Jan 2018
DOIs
Publication statusPublished - 13 Apr 2018

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Bifidobacterium
Enterococcus faecalis
Probiotics
Bile Acids and Salts
Gastrointestinal Transit
Tetracycline Resistance
Microbial Drug Resistance
Genes
Bacteria
Safety

Bibliographical note

This is an open-access article distributed under the terms of the Creative
Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
(CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Investigating the transmissibility of tet(W) in bifidobacteria exposed to acid and bile stress. / Polit, Agnieszka; Yang, Huiying; Amund, Daniel.

In: Bioscience of Microbiota, Food and Health, Vol. 37, No. 2, 13.04.2018, p. 39-43.

Research output: Contribution to journal › Article

Polit, A, Yang, H & Amund, D 2018, 'Investigating the transmissibility of tet(W) in bifidobacteria exposed to acid and bile stress' Bioscience of Microbiota, Food and Health, vol. 37, no. 2, pp. 39-43. https://doi.org/10.12938/bmfh.17-017
Polit A, Yang H, Amund D. Investigating the transmissibility of tet(W) in bifidobacteria exposed to acid and bile stress. Bioscience of Microbiota, Food and Health. 2018 Apr 13;37(2):39-43. https://doi.org/10.12938/bmfh.17-017
Polit, Agnieszka ; Yang, Huiying ; Amund, Daniel. / Investigating the transmissibility of tet(W) in bifidobacteria exposed to acid and bile stress. In: Bioscience of Microbiota, Food and Health. 2018 ; Vol. 37, No. 2. pp. 39-43.
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