Investigating Cardiac Optical Signal Dynamics in Guinea Pigs Using Directed Information

Hira Shahid; Yuhang Xu; Wing Chiu Tong; Michael Taggart; Dingchang Zheng

doi:10.1109/EMBC53108.2024.10782099

Investigating Cardiac Optical Signal Dynamics in Guinea Pigs Using Directed Information

Hira Shahid
, Yuhang Xu
, Wing Chiu Tong
, Michael Taggart
, Dingchang Zheng

Newcastle University

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding › peer-review

70 Downloads (Pure)

Abstract

Investigating the bio-electrical propagation could potentially facilitate understanding of the underlying physiological mechanisms of the bio-electrical activities, and thus enhancing disease diagnosis. High-spatial-resolution optical mapping technique has been used to examine the cardiac electrical propagation. However, it is expensive, requires more computational resource, and has limitations in clinical settings. This study offers a unique contribution to the development and optimization of the directed information (DI)-based method to estimate the cardiac excitation propagation. This method was applied to the cardiac optical excitation signals acquired from adult guinea pig's heart. The results of our method using cardiac action potentials of low-spatial resolution were compared to the excitation propagation observed in the cardiac optical mapping images of high-spatial-resolution. The results showed the remarkable ability of our method to provide intricate and complex details using low-spatial-resolution data, which are difficult to visualize from the cardiac optical recordings, offering a more realistic representation of the clinical scenarios.

Original language	English
Title of host publication	2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Publisher	IEEE
Number of pages	4
ISBN (Electronic)	9798350371499
ISBN (Print)	979835037150-5
DOIs	https://doi.org/10.1109/EMBC53108.2024.10782099
Publication status	E-pub ahead of print - 17 Dec 2024
Event	46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Orlando, FL, USA, Orlando, United States Duration: 15 Jul 2024 → 19 Jul 2024 https://embc.embs.org/2024/

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Publisher	IEEE
ISSN (Print)	2375-7477
ISSN (Electronic)	2694-0604

Conference

Conference	46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated title	IEEE EMBS
Country/Territory	United States
City	Orlando
Period	15/07/24 → 19/07/24
Internet address	https://embc.embs.org/2024/

Bibliographical note

© 2024 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it

Funding

This work was supported by MRC (G0902091 and MR/L0009560/1), NIHR AI Award (AI_AWARD02312) and GCRF Fully Funded Doctoral Studentship.

Funders	Funder number
Global Challenges Research Fund
Medical Research Council	G0902091, MR/L0009560/1
Medical Research Council
National Institute for Health and Care Research	AI-AWARD02312
National Institute for Health and Care Research

Keywords

Heart
Biomedical optical imaging
Action potentials
Image resolution
Optical recording
Optical propagation
Optical imaging
Medical diagnosis
Signal resolution
Optimization

Access to Document

10.1109/EMBC53108.2024.10782099

Xu2024AAMAccepted author manuscript, 992 KB

Cite this

Shahid, H., Xu, Y., Tong, W. C., Taggart, M., & Zheng, D. (2024). Investigating Cardiac Optical Signal Dynamics in Guinea Pigs Using Directed Information. In 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). IEEE. Advance online publication. https://doi.org/10.1109/EMBC53108.2024.10782099

Investigating Cardiac Optical Signal Dynamics in Guinea Pigs Using Directed Information. / Shahid, Hira ; Xu, Yuhang; Tong, Wing Chiu et al.
2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2024. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding › peer-review

Shahid, H , Xu, Y, Tong, WC, Taggart, M & Zheng, D 2024, Investigating Cardiac Optical Signal Dynamics in Guinea Pigs Using Directed Information. in 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, IEEE, 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Orlando, Florida, United States, 15/07/24. https://doi.org/10.1109/EMBC53108.2024.10782099

Shahid H , Xu Y, Tong WC, Taggart M, Zheng D. Investigating Cardiac Optical Signal Dynamics in Guinea Pigs Using Directed Information. In 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE. 2024. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Epub 2024 Dec 17. doi: 10.1109/EMBC53108.2024.10782099

Shahid, Hira ; Xu, Yuhang ; Tong, Wing Chiu et al. / Investigating Cardiac Optical Signal Dynamics in Guinea Pigs Using Directed Information. 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2024. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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Investigating Cardiac Optical Signal Dynamics in Guinea Pigs Using Directed Information

Abstract

Publication series

Conference

Bibliographical note

Funding

Keywords

Access to Document

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Cite this