Interventions to restore appropriate immune function in the elderly

Richard Aspinall, Pierre Olivier Lang

Research output: Contribution to journalReview article

7 Citations (Scopus)
15 Downloads (Pure)

Abstract

Advanced age is one indicator of likely immune dysfunction. As worldwide, the global population contains progressively more and more older individuals there is likelihood of an increased prevalence and incidence of infectious diseases due to common and emergent pathogens. The resultant increase in mortality and morbidity would be matched by the risk of functional decline and disability. Maintaining immune function at a plateau throughout life may therefore be associated with considerable cost savings. The aim of improving immune function in older individuals may be achieved through considering a therapeutic approach to rejuvenate, stimulate or support the indigenous immune system to perform in a more optimal manner. In terms of cost effectiveness a therapeutic approach may prove difficult because of issues associated with; identifying those who would benefit the most from this treatment, identifying the type of treatment which would suit them and identifying whether the treatment was successful. The alternative of supporting or providing a stronger stimulus through vaccination, whilst more cost effective, may be a more valuable option in the short term. Both approaches will be addressed in this review.

Original languageEnglish
Article number5
JournalImmunity and Ageing
Volume15
Issue number1
DOIs
Publication statusPublished - 25 Jan 2018
Externally publishedYes

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Therapeutics
Cost Savings
Cost-Benefit Analysis
Communicable Diseases
Immune System
Vaccination
Morbidity
Costs and Cost Analysis
Mortality
Incidence
Population

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

ASJC Scopus subject areas

  • Immunology
  • Ageing

Cite this

Interventions to restore appropriate immune function in the elderly. / Aspinall, Richard; Lang, Pierre Olivier.

In: Immunity and Ageing, Vol. 15, No. 1, 5, 25.01.2018.

Research output: Contribution to journalReview article

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