Interleukin-7: An interleukin for rejuvenating the immune system

Richard Aspinall; Sian Henson; Jeffrey Pido-Lopez; Pa Tamba Ngom

doi:10.1196/annals.1297.021

Interleukin-7: An interleukin for rejuvenating the immune system

Richard Aspinall, Sian Henson, Jeffrey Pido-Lopez, Pa Tamba Ngom

Imperial College London

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Infection of an individual (aged 20-30 years) by a virus will cause a response from the T (thymus derived) lymphocytes of which there are approximately 3 × 10¹¹. If the individual has not met the virus before, the response will come from the naive T cell subset (50 ± 10% of the total T cell pool at this age) containing recent thymic emigrants produced from the thymus at approximately 10⁸ per day. Their antigen-specific receptor has a defined specificity governed by the conformation of its two chains (α and β), and the repertoire of specificities is somewhere in the region of 2 × 10⁷ to 10⁸. A successful response leads to clonal expansion and the generation of memory T cells to the infecting agent.

Original language	English
Pages (from-to)	116-122
Number of pages	7
Journal	Annals of the New York Academy of Sciences
Volume	1019
DOIs	https://doi.org/10.1196/annals.1297.021
Publication status	Published - Jun 2004
Externally published	Yes

Keywords

Aging
Antigen-specific receptor
T cell

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

Access to Document

10.1196/annals.1297.021

Cite this

@article{eec5fab81a3d46c0956dab5ae65b102f,

title = "Interleukin-7: An interleukin for rejuvenating the immune system",

abstract = "Infection of an individual (aged 20-30 years) by a virus will cause a response from the T (thymus derived) lymphocytes of which there are approximately 3 × 1011. If the individual has not met the virus before, the response will come from the naive T cell subset (50 ± 10% of the total T cell pool at this age) containing recent thymic emigrants produced from the thymus at approximately 108 per day. Their antigen-specific receptor has a defined specificity governed by the conformation of its two chains (α and β), and the repertoire of specificities is somewhere in the region of 2 × 107 to 108. A successful response leads to clonal expansion and the generation of memory T cells to the infecting agent.",

keywords = "Aging, Antigen-specific receptor, T cell",

author = "Richard Aspinall and Sian Henson and Jeffrey Pido-Lopez and Ngom, {Pa Tamba}",

year = "2004",

month = jun,

doi = "10.1196/annals.1297.021",

language = "English",

volume = "1019",

pages = "116--122",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "Wiley",

}

TY - JOUR

T1 - Interleukin-7

T2 - An interleukin for rejuvenating the immune system

AU - Aspinall, Richard

AU - Henson, Sian

AU - Pido-Lopez, Jeffrey

AU - Ngom, Pa Tamba

PY - 2004/6

Y1 - 2004/6

N2 - Infection of an individual (aged 20-30 years) by a virus will cause a response from the T (thymus derived) lymphocytes of which there are approximately 3 × 1011. If the individual has not met the virus before, the response will come from the naive T cell subset (50 ± 10% of the total T cell pool at this age) containing recent thymic emigrants produced from the thymus at approximately 108 per day. Their antigen-specific receptor has a defined specificity governed by the conformation of its two chains (α and β), and the repertoire of specificities is somewhere in the region of 2 × 107 to 108. A successful response leads to clonal expansion and the generation of memory T cells to the infecting agent.

AB - Infection of an individual (aged 20-30 years) by a virus will cause a response from the T (thymus derived) lymphocytes of which there are approximately 3 × 1011. If the individual has not met the virus before, the response will come from the naive T cell subset (50 ± 10% of the total T cell pool at this age) containing recent thymic emigrants produced from the thymus at approximately 108 per day. Their antigen-specific receptor has a defined specificity governed by the conformation of its two chains (α and β), and the repertoire of specificities is somewhere in the region of 2 × 107 to 108. A successful response leads to clonal expansion and the generation of memory T cells to the infecting agent.

KW - Aging

KW - Antigen-specific receptor

KW - T cell

UR - http://www.scopus.com/inward/record.url?scp=3242732995&partnerID=8YFLogxK

U2 - 10.1196/annals.1297.021

DO - 10.1196/annals.1297.021

M3 - Article

C2 - 15247003

AN - SCOPUS:3242732995

SN - 0077-8923

VL - 1019

SP - 116

EP - 122

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Interleukin-7: An interleukin for rejuvenating the immune system

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this