Infection of an individual (aged 20-30 years) by a virus will cause a response from the T (thymus derived) lymphocytes of which there are approximately 3 × 1011. If the individual has not met the virus before, the response will come from the naive T cell subset (50 ± 10% of the total T cell pool at this age) containing recent thymic emigrants produced from the thymus at approximately 108 per day. Their antigen-specific receptor has a defined specificity governed by the conformation of its two chains (α and β), and the repertoire of specificities is somewhere in the region of 2 × 107 to 108. A successful response leads to clonal expansion and the generation of memory T cells to the infecting agent.
- Antigen-specific receptor
- T cell
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science