Interleukin-7: An interleukin for rejuvenating the immune system

Richard Aspinall, Sian Henson, Jeffrey Pido-Lopez, Pa Tamba Ngom

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Infection of an individual (aged 20-30 years) by a virus will cause a response from the T (thymus derived) lymphocytes of which there are approximately 3 × 1011. If the individual has not met the virus before, the response will come from the naive T cell subset (50 ± 10% of the total T cell pool at this age) containing recent thymic emigrants produced from the thymus at approximately 108 per day. Their antigen-specific receptor has a defined specificity governed by the conformation of its two chains (α and β), and the repertoire of specificities is somewhere in the region of 2 × 107 to 108. A successful response leads to clonal expansion and the generation of memory T cells to the infecting agent.

Original languageEnglish
Pages (from-to)116-122
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1019
DOIs
Publication statusPublished - Jun 2004
Externally publishedYes

Keywords

  • Aging
  • Antigen-specific receptor
  • T cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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