In vitro cytocompatibility of a Zr-based metallic glass modified by laser surface texturing for potential implant applications

Yang Jiao, Emmanuel Brousseau, Wayne Nishio Ayre, Edward Gait-Carr, Xiaojun Shen, Xiaoxiang Wang, Samuel Bigot, Hanxing Zhu, Weifeng He

Research output: Contribution to journalArticlepeer-review

Abstract

Existing studies have shown the benefit of laser surface texturing (LST) in promoting the cytocompatibility of traditional metallic biomaterials. Researchers have also reported the potential of bulk metallic glasses (BMGs) as an alternative class of material for biomedical applications. However, investigations specifically focussed on studying the cytocompatibility of BMG surfaces processed with LST are still lacking. The present work demonstrated the feasibility of nanosecond LST as a method to modify the cytocompatibility of a Zr-based BMG material known as Vitreloy 105. Two different types of laser-induced surface patterns, namely grooves and dimples, were considered. Their respective influence on the resulting cell viability, attachment and morphology was studied and compared against the cytocompatibility of the original BMG surface. It was found that MG63 osteoblast-like cells on the groove-textured surface exhibited higher viability and better adhesion compared to those on the original and dimple-textured surfaces. Possible underlying mechanisms associated with LST, which can affect the in vitro cytocompatibility of Vitreloy 105 were discussed based on the induced changes to surface chemistry, wettability and roughness. It is suggested that the higher surface roughness, increased presence of metallic oxides and enhanced hydrophilicity of the groove-textured sample were the main contributors to its improved cytocompatibility.

Original languageEnglish
Article number149194
JournalApplied Surface Science
Volume547
Early online date1 Feb 2021
DOIs
Publication statusE-pub ahead of print - 1 Feb 2021

Bibliographical note

Funding Information:
The authors would like to thank Mrs Jiamei Liu from the Instrumental Analysis Center of Xi'an Jiaotong University for her assistance in the XPS measurements; Dr David Waugh from Coventry University for his help in contact angle measurement and Dr Shahin Mehraban from Swansea University for the provision of the DSC data. The lead author (Yang Jiao) gratefully appreciates the financial support from Cardiff University, UK and Xi'an Jiaotong University, China. Emmanuel Brousseau gratefully acknowledges the financial support provided by the Welsh Government and Higher Education Funding Council for Wales through the S?r Cymru National Research Network in Advanced Engineering and Materials.

Funding Information:
The authors would like to thank Mrs Jiamei Liu from the Instrumental Analysis Center of Xi'an Jiaotong University for her assistance in the XPS measurements; Dr David Waugh from Coventry University for his help in contact angle measurement and Dr Shahin Mehraban from Swansea University for the provision of the DSC data. The lead author (Yang Jiao) gratefully appreciates the financial support from Cardiff University, UK and Xi’an Jiaotong University, China. Emmanuel Brousseau gratefully acknowledges the financial support provided by the Welsh Government and Higher Education Funding Council for Wales through the Sêr Cymru National Research Network in Advanced Engineering and Materials.

Publisher Copyright:
© 2021 Elsevier B.V.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

  • Biocompatibility
  • Bulk metallic glass
  • Laser surface texturing
  • MG63 osteoblast-like cells
  • Vitreloy 105

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Physics and Astronomy(all)
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films

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