Improving rehabilitation after critical illness through outpatient physiotherapy classes and essential amino acid supplement: A randomized controlled trial.

C Jones, J Eddleston, A McCairn, S Dowling, D McWilliams, E Coughlan, RD Griffiths

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Purpose Patients recovering from critical illness may be left with significant muscle mass loss. This study aimed to evaluate whether a 6-week program of enhanced physiotherapy and structured exercise (PEPSE) and an essential amino acid supplement drink (glutamine and essential amino acid mixture [GEAA]) improves physical and psychological recovery. Materials and methods Intensive care patients aged 45 years or older, with a combined intensive care unit stay/pre–intensive care unit stay of 5 days or more were recruited to a randomized controlled trial examining the effect of PEPSE and GEAA on recovery. The 2 factors were tested in a 2 × 2 factorial design: (1) GEAA drink twice daily for 3 months and (2) 6-week PEPSE in first 3 months. Primary efficacy outcome was an improvement in the 6-minute walking test at 3 months. Results A total of 93 patients were randomized to the study. Patients receiving the PEPSE and GEA had the biggest gains in distance walked in 6-minute walking test (P < .0001). There were also significant reductions in rates of anxiety in study groups control supplement/PEPSE (P = .047) and GEAA supplement/PEPSE (P = .036) and for GEAA supplement/PEPSE in depression (P = .0009). Conclusion Enhanced rehabilitation combined with GEAA supplement may enhance physical recovery and reduce anxiety and depression.
Original languageEnglish
Pages (from-to)901-907
Number of pages7
JournalJournal of Critical Care
Volume30
Issue number5
Early online date2 May 2015
DOIs
Publication statusPublished - Oct 2015
Externally publishedYes

Keywords

  • 6 minute walk test
  • Anxiety
  • Depression
  • Intervention
  • Supplement
  • Physiotherapy

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