Impact of fetal growth and preterm birth on the retinal microvasculature in mid-adulthood

Sultana Monira Hussain, Mika Kähönen, Olli T Raitakari, Michael R Skilton, Nicholas Witt, Nish Chaturvedi, Nina Hutri-Kähönen, Terho Lehtimäki, Hanna Vaahtoranta-Lehtonen, Markus Juonala, Sumangali Wijetunge, Alun D Hughes, Simon A McG Thom, Andrew Metha, Robyn J Tapp

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVE: We hypothesized that preterm birth and being born SGA would be associated with changes in retinal microvascular architecture and that these changes would be more marked among those born preterm. We further hypothesized that these microvascular changes would correlate with early markers of CVD in mid-adulthood.

METHODS: The Cardiovascular Risk in Young Finns Study included randomly selected children from 5 Finnish University cities. Retinal microvascular architecture of participants born preterm, born at term and SGA and a control group born at term and AGA were compared (aged 34-49 years).

RESULTS: In participants born preterm, arteriolar tortuosity (×10(2)) was higher-means (standard error), 0.06 (0.01) versus 0.04 (0.01), p = 0.001, arteriolar length (pixels) were greater-644.9 (35.9) versus 591.7 (33.5), p = 0.007 and arteriolar diameters (pixels) were narrower-19.9 (0.4) versus 20.3 (0.3), p = 0.034 compared to participants born AGA, after adjustment. In participants born SGA, only arteriolar tortuosity was higher-0.05 (0.01) versus 0.04 (0.01), p = 0.074 compared to participants born AGA.

CONCLUSION: This study demonstrated that being born SGA and in particular preterm birth are associated with changes in retinal microvascular architecture. The prenatal and immediate postnatal environment may contribute to the mechanisms.

Original languageEnglish
Pages (from-to)285-293
Number of pages9
JournalMicrocirculation
Volume22
Issue number4
Early online date25 Apr 2015
DOIs
Publication statusPublished - May 2015
Externally publishedYes

Bibliographical note

© 2015 John Wiley & Sons Ltd.

Keywords

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Fetal Development
  • Follow-Up Studies
  • Humans
  • Male
  • Microcirculation
  • Middle Aged
  • Premature Birth/pathology
  • Retinal Vessels/pathology

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  • Cite this

    Hussain, S. M., Kähönen, M., Raitakari, O. T., Skilton, M. R., Witt, N., Chaturvedi, N., ... Tapp, R. J. (2015). Impact of fetal growth and preterm birth on the retinal microvasculature in mid-adulthood. Microcirculation, 22(4), 285-293. https://doi.org/10.1111/micc.12197