Impact of deprivation, dementia prevalence and regional demography on prescribing of antidementia drugs in England: A time trend analysis

Neha Vohra, Muhammad Abdul Hadi, Saval Khanal, Om P. Kurmi, Vibhu Paudyal

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    2 Citations (Scopus)
    18 Downloads (Pure)

    Abstract

    Aim: This study aimed to examine trends in prescribing of antidementia drugs in primary care in England between 2009 and 2019, and investigate the impact of deprivation, regional demography and disease prevalence on prescribing practices. Methods: Analysis of publicly available government data from various sources pertaining to primary care prescribing and demographics was conducted. All primary care prescription data pertaining to antidementia drugs in England between 2009 and 2019 were extracted and adjusted for inflation and population changes. Data across English clinical commissioning regions were compared to explore the association between prescribing trend, deprivation, regional demography and dementia prevalence. Results: The number of prescription items for antidementia drugs in England increased by approximately 3-fold (195.4%) from 24 items/1000 population in 2009 to 70.9 items/1000 population in 2019. In 2019, the least-deprived areas had approximately twice the rate of prescribing of antidementia drugs compared to the most-deprived areas (median [IQR] values of 46.7 [36.6-64.8] vs 91.23 [76.2-95.1] items/1000 population, respectively). In the multivariable analysis, the number of prescription items showed an inverse relationship with deprivation (coefficient −0.046, 95% CI −0.47 to −0.045) after adjustment for number of populations aged 65+ years and prevalence of dementia. Conclusions: The 3-fold rise in the number of prescription items for antidementia drugs in the study period reflects the policy emphasis on early diagnosis and treatment of dementia. Higher rates of prescribing in the least-deprived areas may be reflective of better and early diagnoses and access to treatments. Such inequality in access to the treatments needs to be investigated further.

    Original languageEnglish
    Pages (from-to)3747-3755
    Number of pages9
    JournalBritish Journal of Clinical Pharmacology
    Volume87
    Issue number10
    Early online date18 Feb 2021
    DOIs
    Publication statusPublished - Oct 2021

    Bibliographical note

    This is an open access article under the terms of the Creative Commons Attribution-Non Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

    Keywords

    • acetylcholinesterase inhibitor
    • antipsychotic drugs
    • dementia
    • N-methyl-d-aspartate receptor antagonist
    • prescription patterns

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

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