Impact of blood pressure on retinal microvasculature architecture across the lifespan: the Young Finns Study

Robyn J Tapp, S Monira Hussain, Josephine Battista, Nina Hutri-Kähönen, Terho Lehtimäki, Alun D Hughes, Simon A McG Thom, Andrew Metha, Olli T Raitakari, Mika Kähönen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVE: The present study examined the impact of BP from childhood to mid-adulthood on retinal microvascular architecture.

METHODS: The Cardiovascular Risk in Young Finns Study included children aged 3-18 years, from five Finnish University cities, with participants chosen randomly from the national population registrar from those areas. The age of participants included in the current analyses in childhood (1980) ranged from three to nine years and in mid-adulthood (2011) ranged from 34 to 40 years (complete data n = 657). Measures of retinal microvasculature architecture measured in adulthood included diameters, tortuosity, lengths, and LDR.

RESULTS: Regression analysis showed a strong negative association between childhood systolic BP and adult arteriolar diameter (standardized regression coefficient [β] -0.300; p < 0.001) and with change in systolic BP from childhood to adulthood (β = -0.249; p < 0.001). For arteriolar tortuosity, there was a strong positive association between childhood systolic BP and adult arteriolar tortuosity (β = 0.154; p < 0.001) and no association with change in systolic BP from childhood to adulthood (β = 0.072; p = 0.110).

CONCLUSIONS: High BP in childhood and increased BP from childhood to adulthood impacts on retinal microvascular architecture in mid-adulthood.

Original languageEnglish
Pages (from-to)146-55
Number of pages10
JournalMicrocirculation (New York, N.Y. : 1994)
Volume22
Issue number2
Early online date6 Jan 2015
DOIs
Publication statusPublished - 12 Feb 2015
Externally publishedYes

Bibliographical note

© 2015 John Wiley & Sons Ltd.

Keywords

  • Adolescent
  • Adult
  • Aging
  • Arterioles/anatomy & histology
  • Blood Pressure
  • Child
  • Child, Preschool
  • Female
  • Finland
  • Humans
  • Male
  • Microcirculation
  • Retinal Vessels/anatomy & histology

Fingerprint Dive into the research topics of 'Impact of blood pressure on retinal microvasculature architecture across the lifespan: the Young Finns Study'. Together they form a unique fingerprint.

Cite this