Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 443-451 |
| Number of pages | 9 |
| Journal | Clinical Nutrition |
| Volume | 37 |
| Issue number | 2 |
| Early online date | 28 Jan 2017 |
| DOIs | |
| Publication status | Published - Apr 2018 |
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Keywords
- Ageing
- Influenza
- Probiotic
- Lymphocyte
- Vaccination
Cite this
Impact of ageing and a synbiotic on the immune response to seasonal influenza vaccination; a randomised controlled trial. / Enani, Sumia ; Przemska-Kosicka, Agnieszka; Childs, Caroline E; Maidens, Catherine ; Dong, Honglin; Conterno, Lorenza; Tuohy, Kieran ; Todd, Susan; Gosney, Margot; Yaqoob, Parveen.
In: Clinical Nutrition, Vol. 37, No. 2, 04.2018, p. 443-451.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Impact of ageing and a synbiotic on the immune response to seasonal influenza vaccination; a randomised controlled trial
AU - Enani, Sumia
AU - Przemska-Kosicka, Agnieszka
AU - Childs, Caroline E
AU - Maidens, Catherine
AU - Dong, Honglin
AU - Conterno, Lorenza
AU - Tuohy, Kieran
AU - Todd, Susan
AU - Gosney, Margot
AU - Yaqoob, Parveen
PY - 2018/4
Y1 - 2018/4
N2 - Background & aims: Ageing increases risk of respiratory infections and impairs the response to influenza vaccination. Pre- and pro-biotics offer an opportunity to modulate anti-viral defenses and the response to vaccination via alteration of the gut microbiota. This study investigated the effect of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486, combined with a prebiotic, gluco-oligosaccharide, on the B and T cell response to seasonal influenza vaccination in young and older subjects . Methods: In a double-blind, randomized controlled trial, 58 young (18e35 y) and 54 older (60e85 y) subjects were supplemented with the synbiotic for 8 weeks. At 4 weeks they were administered with a seasonal influenza vaccine. B and T cell phenotype and responsiveness to in vitro re-stimulation with the vaccine were assessed at baseline, 4, 6 and 8 weeks. Results: B and T cell profiles differed markedly between young and older subjects. Vaccination increased numbers of memory, IgAþ memory, IgGþ memory and total IgGþ B cells in young subjects, but failed to do so in older subjects and did not significantly alter T cell subsets. Seroconversion to the H1N1 subunit in the older subjects was associated with higher post-vaccination numbers of plasma B cells, but seroconversion was less consistently associated with T cell phenotype. B and T cell subsets from both young and older subjects demonstrated a strong antigen-specific recall challenge, and although not influenced by age, responsiveness to the recall challenge was associated with seroconversion. In older subjects, CMV seropositivity was associated with a significantly lower recall response to the vaccine, but the synbiotic did not affect the responsiveness of B or T cells to re-stimulation with influenza vaccine. Conclusions: Antigen-specific B and T cell activation following an in vitro recall challenge with the influenza vaccine was influenced by CMV seropositivity, but not by a synbiotic.
AB - Background & aims: Ageing increases risk of respiratory infections and impairs the response to influenza vaccination. Pre- and pro-biotics offer an opportunity to modulate anti-viral defenses and the response to vaccination via alteration of the gut microbiota. This study investigated the effect of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486, combined with a prebiotic, gluco-oligosaccharide, on the B and T cell response to seasonal influenza vaccination in young and older subjects . Methods: In a double-blind, randomized controlled trial, 58 young (18e35 y) and 54 older (60e85 y) subjects were supplemented with the synbiotic for 8 weeks. At 4 weeks they were administered with a seasonal influenza vaccine. B and T cell phenotype and responsiveness to in vitro re-stimulation with the vaccine were assessed at baseline, 4, 6 and 8 weeks. Results: B and T cell profiles differed markedly between young and older subjects. Vaccination increased numbers of memory, IgAþ memory, IgGþ memory and total IgGþ B cells in young subjects, but failed to do so in older subjects and did not significantly alter T cell subsets. Seroconversion to the H1N1 subunit in the older subjects was associated with higher post-vaccination numbers of plasma B cells, but seroconversion was less consistently associated with T cell phenotype. B and T cell subsets from both young and older subjects demonstrated a strong antigen-specific recall challenge, and although not influenced by age, responsiveness to the recall challenge was associated with seroconversion. In older subjects, CMV seropositivity was associated with a significantly lower recall response to the vaccine, but the synbiotic did not affect the responsiveness of B or T cells to re-stimulation with influenza vaccine. Conclusions: Antigen-specific B and T cell activation following an in vitro recall challenge with the influenza vaccine was influenced by CMV seropositivity, but not by a synbiotic.
KW - Ageing
KW - Influenza
KW - Probiotic
KW - Lymphocyte
KW - Vaccination
U2 - 10.1016/j.clnu.2017.01.011
DO - 10.1016/j.clnu.2017.01.011
M3 - Article
VL - 37
SP - 443
EP - 451
JO - Clinical Nutrition ESPEN
JF - Clinical Nutrition ESPEN
SN - 0261-5614
IS - 2
ER -