Impact of adiposity on cardiac structure in adult life: the Childhood Determinants of Adult Health (CDAH) study

Robyn J Tapp; Alison Venn; Quan L Huynh; Olli T Raitakari; Obioha C Ukoumunne; Terence Dwyer; Costan G Magnussen

doi:10.1186/1471-2261-14-79

Impact of adiposity on cardiac structure in adult life: the Childhood Determinants of Adult Health (CDAH) study

Robyn J Tapp, Alison Venn, Quan L Huynh, Olli T Raitakari, Obioha C Ukoumunne, Terence Dwyer, Costan G Magnussen

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Abstract

BACKGROUND: We have examined the association between adiposity and cardiac structure in adulthood, using a life course approach that takes account of the contribution of adiposity in both childhood and adulthood.

METHODS: The Childhood Determinants of Adult Health study (CDAH) is a follow-up study of 8,498 children who participated in the 1985 Australian Schools Health and Fitness Survey (ASHFS). The CDAH follow-up study included 2,410 participants who attended a clinic examination. Of these, 181 underwent cardiac imaging and provided complete data. The measures were taken once when the children were aged 9 to 15 years, and once in adult life, aged 26 to 36 years.

RESULTS: There was a positive association between adult left ventricular mass (LVM) and childhood body mass index (BMI) in males (regression coefficient (β) 0.41; 95% confidence interval (CI): 0.14 to 0.67; p = 0.003), and females (β = 0.53; 95% CI: 0.34 to 0.72; p < 0.001), and with change in BMI from childhood to adulthood (males: β = 0.27; 95% CI: 0.04 to 0.51; p < 0.001, females: β = 0.39; 95% CI: 0.20 to 0.58; p < 0.001), after adjustment for confounding factors (age, fitness, triglyceride levels and total cholesterol in adulthood). After further adjustment for known potential mediating factors (systolic BP and fasting plasma glucose in adulthood) the relationship of LVM with childhood BMI (males: β = 0.45; 95% CI: 0.19 to 0.71; p = 0.001, females: β = 0.49; 95% CI: 0.29 to 0.68; p < 0.001) and change in BMI (males: β = 0.26; 95% CI: 0.04 to 0.49; p = 0.02, females: β = 0.40; 95% CI: 0.20 to 0.59; p < 0.001) did not change markedly.

CONCLUSIONS: Adiposity and increased adiposity from childhood to adulthood appear to have a detrimental effect on cardiac structure.

Original language	English
Article number	79
Number of pages	10
Journal	BMC Cardiovascular Disorders
Volume	14
DOIs	https://doi.org/10.1186/1471-2261-14-79
Publication status	Published - 1 Jul 2014
Externally published	Yes

Bibliographical note

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

Keywords

Adiposity
Adolescent
Adult
Age Factors
Australia
Body Mass Index
Child
Female
Follow-Up Studies
Health Surveys
Heart Diseases/diagnostic imaging
Heart Ventricles/diagnostic imaging
Humans
Longitudinal Studies
Male
Obesity/complications
Risk Factors
Sex Factors
Time Factors
Ultrasonography

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/1471-2261-14-79Licence: CC BY

PublishedFinal published version, 518 KBLicence: CC BY

Cite this

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title = "Impact of adiposity on cardiac structure in adult life: the Childhood Determinants of Adult Health (CDAH) study",

abstract = "BACKGROUND: We have examined the association between adiposity and cardiac structure in adulthood, using a life course approach that takes account of the contribution of adiposity in both childhood and adulthood.METHODS: The Childhood Determinants of Adult Health study (CDAH) is a follow-up study of 8,498 children who participated in the 1985 Australian Schools Health and Fitness Survey (ASHFS). The CDAH follow-up study included 2,410 participants who attended a clinic examination. Of these, 181 underwent cardiac imaging and provided complete data. The measures were taken once when the children were aged 9 to 15 years, and once in adult life, aged 26 to 36 years.RESULTS: There was a positive association between adult left ventricular mass (LVM) and childhood body mass index (BMI) in males (regression coefficient (β) 0.41; 95% confidence interval (CI): 0.14 to 0.67; p = 0.003), and females (β = 0.53; 95% CI: 0.34 to 0.72; p < 0.001), and with change in BMI from childhood to adulthood (males: β = 0.27; 95% CI: 0.04 to 0.51; p < 0.001, females: β = 0.39; 95% CI: 0.20 to 0.58; p < 0.001), after adjustment for confounding factors (age, fitness, triglyceride levels and total cholesterol in adulthood). After further adjustment for known potential mediating factors (systolic BP and fasting plasma glucose in adulthood) the relationship of LVM with childhood BMI (males: β = 0.45; 95% CI: 0.19 to 0.71; p = 0.001, females: β = 0.49; 95% CI: 0.29 to 0.68; p < 0.001) and change in BMI (males: β = 0.26; 95% CI: 0.04 to 0.49; p = 0.02, females: β = 0.40; 95% CI: 0.20 to 0.59; p < 0.001) did not change markedly.CONCLUSIONS: Adiposity and increased adiposity from childhood to adulthood appear to have a detrimental effect on cardiac structure.",

keywords = "Adiposity, Adolescent, Adult, Age Factors, Australia, Body Mass Index, Child, Female, Follow-Up Studies, Health Surveys, Heart Diseases/diagnostic imaging, Heart Ventricles/diagnostic imaging, Humans, Longitudinal Studies, Male, Obesity/complications, Risk Factors, Sex Factors, Time Factors, Ultrasonography",

author = "Tapp, {Robyn J} and Alison Venn and Huynh, {Quan L} and Raitakari, {Olli T} and Ukoumunne, {Obioha C} and Terence Dwyer and Magnussen, {Costan G}",

note = "This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.",

year = "2014",

month = jul,

day = "1",

doi = "10.1186/1471-2261-14-79",

language = "English",

volume = "14",

journal = "BMC Cardiovascular Disorders",

issn = "1471-2261",

publisher = "BioMed Central",

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TY - JOUR

T1 - Impact of adiposity on cardiac structure in adult life

T2 - the Childhood Determinants of Adult Health (CDAH) study

AU - Tapp, Robyn J

AU - Venn, Alison

AU - Huynh, Quan L

AU - Raitakari, Olli T

AU - Ukoumunne, Obioha C

AU - Dwyer, Terence

AU - Magnussen, Costan G

N1 - This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

PY - 2014/7/1

Y1 - 2014/7/1

N2 - BACKGROUND: We have examined the association between adiposity and cardiac structure in adulthood, using a life course approach that takes account of the contribution of adiposity in both childhood and adulthood.METHODS: The Childhood Determinants of Adult Health study (CDAH) is a follow-up study of 8,498 children who participated in the 1985 Australian Schools Health and Fitness Survey (ASHFS). The CDAH follow-up study included 2,410 participants who attended a clinic examination. Of these, 181 underwent cardiac imaging and provided complete data. The measures were taken once when the children were aged 9 to 15 years, and once in adult life, aged 26 to 36 years.RESULTS: There was a positive association between adult left ventricular mass (LVM) and childhood body mass index (BMI) in males (regression coefficient (β) 0.41; 95% confidence interval (CI): 0.14 to 0.67; p = 0.003), and females (β = 0.53; 95% CI: 0.34 to 0.72; p < 0.001), and with change in BMI from childhood to adulthood (males: β = 0.27; 95% CI: 0.04 to 0.51; p < 0.001, females: β = 0.39; 95% CI: 0.20 to 0.58; p < 0.001), after adjustment for confounding factors (age, fitness, triglyceride levels and total cholesterol in adulthood). After further adjustment for known potential mediating factors (systolic BP and fasting plasma glucose in adulthood) the relationship of LVM with childhood BMI (males: β = 0.45; 95% CI: 0.19 to 0.71; p = 0.001, females: β = 0.49; 95% CI: 0.29 to 0.68; p < 0.001) and change in BMI (males: β = 0.26; 95% CI: 0.04 to 0.49; p = 0.02, females: β = 0.40; 95% CI: 0.20 to 0.59; p < 0.001) did not change markedly.CONCLUSIONS: Adiposity and increased adiposity from childhood to adulthood appear to have a detrimental effect on cardiac structure.

AB - BACKGROUND: We have examined the association between adiposity and cardiac structure in adulthood, using a life course approach that takes account of the contribution of adiposity in both childhood and adulthood.METHODS: The Childhood Determinants of Adult Health study (CDAH) is a follow-up study of 8,498 children who participated in the 1985 Australian Schools Health and Fitness Survey (ASHFS). The CDAH follow-up study included 2,410 participants who attended a clinic examination. Of these, 181 underwent cardiac imaging and provided complete data. The measures were taken once when the children were aged 9 to 15 years, and once in adult life, aged 26 to 36 years.RESULTS: There was a positive association between adult left ventricular mass (LVM) and childhood body mass index (BMI) in males (regression coefficient (β) 0.41; 95% confidence interval (CI): 0.14 to 0.67; p = 0.003), and females (β = 0.53; 95% CI: 0.34 to 0.72; p < 0.001), and with change in BMI from childhood to adulthood (males: β = 0.27; 95% CI: 0.04 to 0.51; p < 0.001, females: β = 0.39; 95% CI: 0.20 to 0.58; p < 0.001), after adjustment for confounding factors (age, fitness, triglyceride levels and total cholesterol in adulthood). After further adjustment for known potential mediating factors (systolic BP and fasting plasma glucose in adulthood) the relationship of LVM with childhood BMI (males: β = 0.45; 95% CI: 0.19 to 0.71; p = 0.001, females: β = 0.49; 95% CI: 0.29 to 0.68; p < 0.001) and change in BMI (males: β = 0.26; 95% CI: 0.04 to 0.49; p = 0.02, females: β = 0.40; 95% CI: 0.20 to 0.59; p < 0.001) did not change markedly.CONCLUSIONS: Adiposity and increased adiposity from childhood to adulthood appear to have a detrimental effect on cardiac structure.

KW - Adiposity

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Australia

KW - Body Mass Index

KW - Child

KW - Female

KW - Follow-Up Studies

KW - Health Surveys

KW - Heart Diseases/diagnostic imaging

KW - Heart Ventricles/diagnostic imaging

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Obesity/complications

KW - Risk Factors

KW - Sex Factors

KW - Time Factors

KW - Ultrasonography

U2 - 10.1186/1471-2261-14-79

DO - 10.1186/1471-2261-14-79

M3 - Article

C2 - 24980215

SN - 1471-2261

VL - 14

JO - BMC Cardiovascular Disorders

JF - BMC Cardiovascular Disorders

M1 - 79

ER -

Impact of adiposity on cardiac structure in adult life: the Childhood Determinants of Adult Health (CDAH) study

Abstract

Bibliographical note

Keywords

UN SDGs

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