Impact of a mineral enriched, fibre complex on glycaemic response and satiation in healthy adults: a double‑blind, crossover intervention study

Oana Ancu; Richard Mackenzie; Michael  Patterson; Evone  Dsilva; Gleb E.  Yakubov; Michael  Haynes; Sofia  Kolida; Christopher G.  Stephenson; Adele  Costabile

doi:10.1007/s00394-025-03732-8

Impact of a mineral enriched, fibre complex on glycaemic response and satiation in healthy adults: a double‑blind, crossover intervention study

Oana Ancu, Richard Mackenzie, Michael Patterson, Evone Dsilva, Gleb E. Yakubov, Michael Haynes, Sofia Kolida, Christopher G. Stephenson, Adele Costabile

Centre for Health and Life Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Purpose
To investigate the effects of a chromium-enriched glucomannan-fructooligosaccharide complex (SB) on glycaemic and insulin responses, satiation, and hunger biomarkers in healthy adults.

Methods
Using a double-blind, placebo-controlled, randomised crossover design, we assessed the acute impact of a single 3 g SB dose in 16 healthy adults (BMI 18.5–24.9 kg/m2) during a modified oral glucose tolerance test. On separate days, participants consumed 50 g dextrose or 50 g dextrose with 3 g SB (SBD). Blood glucose and insulin were analysed over 2.5 h. Hunger, fullness, and desire to eat were assessed via visual analogue scales. Additionally, the impact of SB on gastric viscosity was assessed in vitro.

Results
SBD intake significantly reduced the insulin concentration compared to dextrose alone at 45, 75, and 90 min post-intake. Additionally, SBD resulted in significantly greater fullness and a lower desire to eat at 75 min when compared to dextrose (p < 0.05). Although hunger increased over time for both interventions, SBD led to lower hunger, desire to eat, and food desire scores compared to dextrose at 150 min (p < 0.05). The viscosity of SB, even when combined with dextrose, was significantly higher compared to dextrose alone.

Conclusions
These novel findings suggest that SB can modulate insulin response and influence appetite regulation, highlighting its potential use in weight management strategies.

Original language	English
Article number	216
Number of pages	10
Journal	European Journal of Nutrition
Volume	64
Early online date	9 Jun 2025
DOIs	https://doi.org/10.1007/s00394-025-03732-8
Publication status	Published - Aug 2025

Bibliographical note

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

Funding

This research was funded by OptiBiotix Health Plc Research Agreement (LSC/2018/64—Roehampton University and Optibiotix Life Sciences, UK).

Funders	Funder number
University of Roehampton
OptiBiotix Health Plc	LSC/2018/64

Keywords

Appetite regulation
Dietary supplements
Insulin response
Weight management

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

Access to Document

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Cite this

Ancu, O., Mackenzie, R., Patterson, M., Dsilva, E., Yakubov, G. E., Haynes, M., Kolida, S., Stephenson, C. G., & Costabile, A. (2025). Impact of a mineral enriched, fibre complex on glycaemic response and satiation in healthy adults: a double‑blind, crossover intervention study. European Journal of Nutrition , 64, Article 216. https://doi.org/10.1007/s00394-025-03732-8

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abstract = "PurposeTo investigate the effects of a chromium-enriched glucomannan-fructooligosaccharide complex (SB) on glycaemic and insulin responses, satiation, and hunger biomarkers in healthy adults.MethodsUsing a double-blind, placebo-controlled, randomised crossover design, we assessed the acute impact of a single 3 g SB dose in 16 healthy adults (BMI 18.5–24.9 kg/m2) during a modified oral glucose tolerance test. On separate days, participants consumed 50 g dextrose or 50 g dextrose with 3 g SB (SBD). Blood glucose and insulin were analysed over 2.5 h. Hunger, fullness, and desire to eat were assessed via visual analogue scales. Additionally, the impact of SB on gastric viscosity was assessed in vitro.ResultsSBD intake significantly reduced the insulin concentration compared to dextrose alone at 45, 75, and 90 min post-intake. Additionally, SBD resulted in significantly greater fullness and a lower desire to eat at 75 min when compared to dextrose (p < 0.05). Although hunger increased over time for both interventions, SBD led to lower hunger, desire to eat, and food desire scores compared to dextrose at 150 min (p < 0.05). The viscosity of SB, even when combined with dextrose, was significantly higher compared to dextrose alone.ConclusionsThese novel findings suggest that SB can modulate insulin response and influence appetite regulation, highlighting its potential use in weight management strategies.",

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note = "This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.",

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AU - Mackenzie, Richard

AU - Patterson, Michael

AU - Dsilva, Evone

AU - Yakubov, Gleb E.

AU - Haynes, Michael

AU - Kolida, Sofia

AU - Stephenson, Christopher G.

AU - Costabile, Adele

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N2 - PurposeTo investigate the effects of a chromium-enriched glucomannan-fructooligosaccharide complex (SB) on glycaemic and insulin responses, satiation, and hunger biomarkers in healthy adults.MethodsUsing a double-blind, placebo-controlled, randomised crossover design, we assessed the acute impact of a single 3 g SB dose in 16 healthy adults (BMI 18.5–24.9 kg/m2) during a modified oral glucose tolerance test. On separate days, participants consumed 50 g dextrose or 50 g dextrose with 3 g SB (SBD). Blood glucose and insulin were analysed over 2.5 h. Hunger, fullness, and desire to eat were assessed via visual analogue scales. Additionally, the impact of SB on gastric viscosity was assessed in vitro.ResultsSBD intake significantly reduced the insulin concentration compared to dextrose alone at 45, 75, and 90 min post-intake. Additionally, SBD resulted in significantly greater fullness and a lower desire to eat at 75 min when compared to dextrose (p < 0.05). Although hunger increased over time for both interventions, SBD led to lower hunger, desire to eat, and food desire scores compared to dextrose at 150 min (p < 0.05). The viscosity of SB, even when combined with dextrose, was significantly higher compared to dextrose alone.ConclusionsThese novel findings suggest that SB can modulate insulin response and influence appetite regulation, highlighting its potential use in weight management strategies.

AB - PurposeTo investigate the effects of a chromium-enriched glucomannan-fructooligosaccharide complex (SB) on glycaemic and insulin responses, satiation, and hunger biomarkers in healthy adults.MethodsUsing a double-blind, placebo-controlled, randomised crossover design, we assessed the acute impact of a single 3 g SB dose in 16 healthy adults (BMI 18.5–24.9 kg/m2) during a modified oral glucose tolerance test. On separate days, participants consumed 50 g dextrose or 50 g dextrose with 3 g SB (SBD). Blood glucose and insulin were analysed over 2.5 h. Hunger, fullness, and desire to eat were assessed via visual analogue scales. Additionally, the impact of SB on gastric viscosity was assessed in vitro.ResultsSBD intake significantly reduced the insulin concentration compared to dextrose alone at 45, 75, and 90 min post-intake. Additionally, SBD resulted in significantly greater fullness and a lower desire to eat at 75 min when compared to dextrose (p < 0.05). Although hunger increased over time for both interventions, SBD led to lower hunger, desire to eat, and food desire scores compared to dextrose at 150 min (p < 0.05). The viscosity of SB, even when combined with dextrose, was significantly higher compared to dextrose alone.ConclusionsThese novel findings suggest that SB can modulate insulin response and influence appetite regulation, highlighting its potential use in weight management strategies.

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KW - Insulin response

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