Immunosenescence and the 3Rs: Restoration, replacement and reprogramming immunosenescence and its correction

Wayne A. Mitchell; Ryan C. Pink; Antonio Lapenna; Richard Aspinall

doi:10.1007/978-3-0346-0219-8_9

Immunosenescence and the 3Rs: Restoration, replacement and reprogramming immunosenescence and its correction

Wayne A. Mitchell, Ryan C. Pink, Antonio Lapenna, Richard Aspinall

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

One of the hallmarks of ageing is the increased susceptibility to develop age-related diseases such as infections and cancers. This is believed to be favoured by a decline in the function of the innate and adaptive immune systems, a process known as immunosenescence. The current greying of the world population leads to the potential dilemma of increasing life expectancy without the concomitant increase in the quality of life with more individuals acquiring age-related disorders. Ultimately this may have profound socio-economic implications for those in positions of government and strategic policy makers. With this in mind, this chapter reviews the current understanding of some of the causes of immunosenescence and looks to address the question, "Can immunosenescence be corrected or reversed?".

Original language	English
Title of host publication	Immunosenescence
Editors	Andreas Thiel
Publisher	Springer Basel
Pages	175-200
Number of pages	26
ISBN (Electronic)	9783034602198
ISBN (Print)	9783034602181
DOIs	https://doi.org/10.1007/978-3-0346-0219-8_9
Publication status	Published - 1 Jan 2012
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-0346-0219-8_9

Cite this

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AB - One of the hallmarks of ageing is the increased susceptibility to develop age-related diseases such as infections and cancers. This is believed to be favoured by a decline in the function of the innate and adaptive immune systems, a process known as immunosenescence. The current greying of the world population leads to the potential dilemma of increasing life expectancy without the concomitant increase in the quality of life with more individuals acquiring age-related disorders. Ultimately this may have profound socio-economic implications for those in positions of government and strategic policy makers. With this in mind, this chapter reviews the current understanding of some of the causes of immunosenescence and looks to address the question, "Can immunosenescence be corrected or reversed?".

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Immunosenescence and the 3Rs: Restoration, replacement and reprogramming immunosenescence and its correction

Abstract

ASJC Scopus subject areas

UN SDGs

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