Immunosenescence and the 3Rs: Restoration, replacement and reprogramming immunosenescence and its correction

Wayne A. Mitchell, Ryan C. Pink, Antonio Lapenna, Richard Aspinall

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

One of the hallmarks of ageing is the increased susceptibility to develop age-related diseases such as infections and cancers. This is believed to be favoured by a decline in the function of the innate and adaptive immune systems, a process known as immunosenescence. The current greying of the world population leads to the potential dilemma of increasing life expectancy without the concomitant increase in the quality of life with more individuals acquiring age-related disorders. Ultimately this may have profound socio-economic implications for those in positions of government and strategic policy makers. With this in mind, this chapter reviews the current understanding of some of the causes of immunosenescence and looks to address the question, "Can immunosenescence be corrected or reversed?".

Original languageEnglish
Title of host publicationImmunosenescence
EditorsAndreas Thiel
PublisherSpringer Basel
Pages175-200
Number of pages26
ISBN (Electronic)9783034602198
ISBN (Print)9783034602181
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Mitchell, W. A., Pink, R. C., Lapenna, A., & Aspinall, R. (2012). Immunosenescence and the 3Rs: Restoration, replacement and reprogramming immunosenescence and its correction. In A. Thiel (Ed.), Immunosenescence (pp. 175-200). Springer Basel. https://doi.org/10.1007/978-3-0346-0219-8_9