Immunological pathogenesis of main age-related diseases and frailty: Role of immunosenescence

P. O. Lang; W. A. Mitchell; A. Lapenna; D. Pitts; R. Aspinall

doi:10.1016/j.eurger.2010.01.010

Immunological pathogenesis of main age-related diseases and frailty: Role of immunosenescence

P. O. Lang, W. A. Mitchell, A. Lapenna, D. Pitts, R. Aspinall

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Nowadays, it is well known that with advancing age individuals are at an increased susceptibility to develop diseases such as Alzheimer's disease, infectious diseases, cancer, and osteoporosis. Ageing is associated with various changes in immune parameters; therefore many authors have postulated that these age-related diseases could be explained, at least in part, by an overall deregulation of the function of the immune system. Immunosenescence is the term usually used to describe the acquired dysfunctional immunity within the ageing population affecting both innate and adaptive immunity. The present review examines the close involvement of the immunosenescence in the pathogenesis of these main age-related clinical outcomes, insulin resistance and the frailty process.

Original language	English
Pages (from-to)	112-121
Number of pages	10
Journal	European Geriatric Medicine
Volume	1
Issue number	2
Early online date	24 Feb 2010
DOIs	https://doi.org/10.1016/j.eurger.2010.01.010
Publication status	Published - May 2010
Externally published	Yes

Keywords

Age-related diseases
Ageing
Frailty
Immunosenescence
Pathogenesis

ASJC Scopus subject areas

Gerontology
Geriatrics and Gerontology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.eurger.2010.01.010

Cite this

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abstract = "Nowadays, it is well known that with advancing age individuals are at an increased susceptibility to develop diseases such as Alzheimer's disease, infectious diseases, cancer, and osteoporosis. Ageing is associated with various changes in immune parameters; therefore many authors have postulated that these age-related diseases could be explained, at least in part, by an overall deregulation of the function of the immune system. Immunosenescence is the term usually used to describe the acquired dysfunctional immunity within the ageing population affecting both innate and adaptive immunity. The present review examines the close involvement of the immunosenescence in the pathogenesis of these main age-related clinical outcomes, insulin resistance and the frailty process.",

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AU - Lang, P. O.

AU - Mitchell, W. A.

AU - Lapenna, A.

AU - Pitts, D.

AU - Aspinall, R.

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AB - Nowadays, it is well known that with advancing age individuals are at an increased susceptibility to develop diseases such as Alzheimer's disease, infectious diseases, cancer, and osteoporosis. Ageing is associated with various changes in immune parameters; therefore many authors have postulated that these age-related diseases could be explained, at least in part, by an overall deregulation of the function of the immune system. Immunosenescence is the term usually used to describe the acquired dysfunctional immunity within the ageing population affecting both innate and adaptive immunity. The present review examines the close involvement of the immunosenescence in the pathogenesis of these main age-related clinical outcomes, insulin resistance and the frailty process.

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Immunological pathogenesis of main age-related diseases and frailty: Role of immunosenescence

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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