Abstract
A novel chitosan derivative, O-palmitoyl chitosan (OPC) was synthesized from chitosan and palmitoyl chloride using methane-sulfonic acid as a solvent. The success of synthesis was confirmed by Fourier transform infra-red (FT-IR) spectroscopy and proton NMR spectroscopy (H-NMR). Liposomes encapsulating ferrous sulphate as a model hydrophilic drug for intestinal delivery were prepared with or without OPC inclusion (Lipo-Fe and OPC-Lipo-Fe). Entrapment of iron was significantly higher in OPC containing liposomes compared to controls. Quantitative iron absorption from the OPC liposomes was significantly higher (1.5-fold P< 0.05) than free ferrous sulphate controls. Qualitative uptake analysis by confocal imaging using coumarin-6 dye loaded liposomes also indicated higher cellular uptake and internalization of the OPC-containing liposomes. These findings suggest that addition of OPC during liposome preparation creates robust vesicles that have improved mucoadhesive and absorption enhancing properties. The chitosan derivative OPC therefore provides a novel alternative for formulation of delivery vehicles targeting intestinal absorption.
Original language | English |
---|---|
Pages (from-to) | 5837-5848 |
Number of pages | 12 |
Journal | International Journal of Nanomedicine |
Volume | 13 |
DOIs | |
Publication status | Published - 27 Sept 2018 |
Bibliographical note
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.Keywords
- Liposomes
- Ferrous sulphate
- Caco-2
- Gut delivery
- Intestinal absorption
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
Fingerprint
Dive into the research topics of 'Hydrophobically-modified chitosan nanoliposomes for intestinal drug delivery'. Together they form a unique fingerprint.Press/Media
Profiles
-
Derek Renshaw, Centre Director
- Centre for Health and Life Sciences - Centre Director
Person: Professional Services