Hydrophobically-modified chitosan nanoliposomes for intestinal drug delivery

Mohammed Gulrez Zariwala, Harshada Bendre, Anatoliy Markiv, Sebastien Farnaud, Derek Renshaw, Kevin M G Taylor, Satyanarayana Somavarapu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A novel chitosan derivative, O-palmitoyl chitosan (OPC) was synthesized from chitosan and palmitoyl chloride using methane-sulfonic acid as a solvent. The success of synthesis was confirmed by Fourier transform infra-red (FT-IR) spectroscopy and proton NMR spectroscopy (H-NMR). Liposomes encapsulating ferrous sulphate as a model hydrophilic drug for intestinal delivery were prepared with or without OPC inclusion (Lipo-Fe and OPC-Lipo-Fe). Entrapment of iron was significantly higher in OPC containing liposomes compared to controls. Quantitative iron absorption from the OPC liposomes was significantly higher (1.5-fold P< 0.05) than free ferrous sulphate controls. Qualitative uptake analysis by confocal imaging using coumarin-6 dye loaded liposomes also indicated higher cellular uptake and internalization of the OPC-containing liposomes. These findings suggest that addition of OPC during liposome preparation creates robust vesicles that have improved mucoadhesive and absorption enhancing properties. The chitosan derivative OPC therefore provides a novel alternative for formulation of delivery vehicles targeting intestinal absorption.
LanguageEnglish
Pages5837-5848
Number of pages12
JournalInternational Journal of Nanomedicine
Volume13
DOIs
Publication statusPublished - 27 Sep 2018

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Chitosan
Liposomes
Pharmaceutical Preparations
ferrous sulfate
Iron
Sulfonic Acids
Intestinal Absorption
Methane
Fourier Analysis
Protons
Spectrum Analysis
Coloring Agents
Magnetic Resonance Spectroscopy

Bibliographical note

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

Keywords

  • Liposomes
  • Ferrous sulphate
  • Caco-2
  • Gut delivery
  • Intestinal absorption

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Hydrophobically-modified chitosan nanoliposomes for intestinal drug delivery. / Zariwala, Mohammed Gulrez; Bendre, Harshada; Markiv, Anatoliy; Farnaud, Sebastien; Renshaw, Derek; Taylor, Kevin M G; Somavarapu, Satyanarayana.

In: International Journal of Nanomedicine, Vol. 13, 27.09.2018, p. 5837-5848.

Research output: Contribution to journalArticle

Zariwala, Mohammed Gulrez ; Bendre, Harshada ; Markiv, Anatoliy ; Farnaud, Sebastien ; Renshaw, Derek ; Taylor, Kevin M G ; Somavarapu, Satyanarayana. / Hydrophobically-modified chitosan nanoliposomes for intestinal drug delivery. In: International Journal of Nanomedicine. 2018 ; Vol. 13. pp. 5837-5848.
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