Abstract
Macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. Up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro-metastatic genes. On the other hand, macrophages respond to hypoxia by up-regulating several genes which are chief factors in angiogenesis and tumorigenesis. Therefore, in this review article we focus mainly on the role of macrophages during inflammation and discuss their response to hypoxia by regulating a diverse array of transcription factors. We also review the existing literatures on hypoxia and its cellular and molecular mechanism which mediates macrophages activation.
| Original language | English |
|---|---|
| Pages (from-to) | 820-30 |
| Number of pages | 11 |
| Journal | Iranian Journal of Basic Medical Sciences |
| Volume | 17 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2014 |
| Externally published | Yes |
Bibliographical note
This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.Keywords
- Hypoxia
- Hypoxia inducible factors
- Inflammation
- Macrophages