HMB supplementation: clinical and athletic performance-related effects and mechanisms of action

Nelo Eidy Zanchi, Frederico Gerlinger-Romero, Lucas Guimarães-Ferreira, Mário Alves de Siqueira Filho, Vitor Felitti, Fabio Santos Lira, Marília Seelaender, Antonio Herbert Lancha

Research output: Contribution to journalReview articlepeer-review

110 Citations (Scopus)


Amino acids such as leucine and its metabolite α-ketoisocaproate (KIC), are returning to be the focus of studies, mainly because of their anti-catabolic properties, through inhibition of muscle proteolysis and enhancement of protein synthesis. It is clear that these effects may counteract catabolic conditions, as well as enhance skeletal muscle mass and strength in athletes. Moreover, beta-hydroxy-beta-methylbutyrate (HMB) has been shown to produce an important effect in reducing muscle damage induced by mechanical stimuli of skeletal muscle. This review aims to describe the general scientific evidence of KIC and HMB supplementation clinical relevance, as well as their effects (e.g., increases in skeletal muscle mass and/or strength), associated with resistance training or other sports. Moreover, the possible mechanisms of cell signaling regulation leading to increases and/or sparing (during catabolic conditions) of skeletal muscle mass are discussed in detail based on the recent literature.

Original languageEnglish
Pages (from-to)1015-1025
Number of pages11
JournalAmino Acids
Issue number4
Publication statusPublished - 6 Jul 2010
Externally publishedYes


  • HMB
  • leucine
  • Athletic Performance
  • Body Composition
  • Dietary Supplements
  • Nutritional supplements


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