Highly Flexible Electrospun Hybrid (Polyurethane/Dextran/Pyocyanin) Membrane for Antibacterial Activity via Generation of Oxidative Stress

Sunirmal Sheet, Vinothkannan Mohanraj, Saravanakumar Balasubramaniam, Sivakumar Allur Subramaniyan, Satabdi Acharya, Yang Soo Lee

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15 Citations (Scopus)
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Abstract

A hybrid nanofibrous mat consisting of polyurethane, dextran, and 10 wt % of biopigment (i.e., pyocyanin) was facilely fabricated using a direct-conventional electrospinning method. The field emission scanning electron microscopy showed the bead-free fibers with a twisted morphology for the pyocyanin-loaded mat. The addition of pyocyanin enables the unprecedented approach to tailor the hydrophilicity of hybrid mat, as verified from the water contact measurement. Thermomechanical stabilities of electrospun mats were investigated in terms of thermogravimetric analysis, differential scanning calorimetry, and dynamic mechanical analysis. The bacterial inhibition test revealed that the antibacterial activity of electrospun mat containing pyocyanin was 98.54 and 90.2% toward Escherichia coli and Staphylococcus aureus, respectively. By the combined efforts of rapid release of pyocyanin and oxidative stress, the PU–dextran–pyocyanin (PUDP) electrospun mat significantly declined the viable cell number that disrupts the cell morphology. Hence, the proposed PUDP electrospun mat must meet the requirements of efficient antimicrobial material in various applications such as disinfectant wiping, food packaging, and textile industries.
Original languageEnglish
Pages (from-to)14551–14561
Number of pages11
JournalACS Omega
Volume3
Issue number11
Early online date1 Nov 2018
DOIs
Publication statusPublished - 30 Nov 2018
Externally publishedYes

Bibliographical note

This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

Funder

This research was supported by the CBNU Buan Regional Innovation System (Buan RIS) Project (grand no. R0001102). S.S. was supported by research funds of Chonbuk National University in 2017.

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