High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc

Ala’aldeen Al-Halhouli; Zaid Doofesh; Ahmed Albagdady; Andreas Dietzel

doi:10.3390/mi11020151

High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc

Ala’aldeen Al-Halhouli, Zaid Doofesh, Ahmed Albagdady, Andreas Dietzel

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

36 Downloads (Pure)

Abstract

The fabrication and testing of microfluidic spinning compact discs with embedded trapezoidal microchambers for the purpose of inertial microparticle focusing is reported in this article. Microparticle focusing channels require small features that cannot be easily fabricated in acrylic sheets and are complicated to realize in glass by traditional lithography techniques; therefore, the fabrication of microfluidic discs with femtosecond laser ablation is reported for the first time in this paper. It could be demonstrated that high-efficiency inertial focusing of 5 and 10 μm particles is achieved in a channel with trapezoidal microchambers regardless of the direction of disc rotation, which correlates to the dominance of inertial forces over Coriolis forces. To achieve the highest throughput possible, the suspension concentration was increased from 0.001% (w/v) to 0.005% (w/v). The focusing efficiency was 98.7% for the 10 μm particles and 93.75% for the 5 μm particles.

Original language	English
Article number	151
Number of pages	12
Journal	Micromachines
Volume	11
Issue number	2
DOIs	https://doi.org/10.3390/mi11020151
Publication status	Published - 30 Jan 2020
Externally published	Yes

Bibliographical note

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Funder

This research is financially supported by the German Academic Exchange Service (DAAD) project, entitled “Inertial focusing for continuous nanoparticles separation in femtosecond laser 3D micromachined curved channels”. This project has also received funding from the Deanship of Scientific Research in the German Jordanian University under grant number SATS03/2018. We acknowledge support by the German Research Foundation and the Open Access Publication Funds of the Technische Universität Braunschweig.

Keywords

microfluidics
femtosecond laser
microparticle separation
microfluidic disc

ASJC Scopus subject areas

Mechanical Engineering
Electrical and Electronic Engineering
Control and Systems Engineering

Access to Document

10.3390/mi11020151Licence: CC BY

Albagdady2020VoRFinal published version, 1.53 MBLicence: CC BY

Cite this

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title = "High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc",

abstract = "The fabrication and testing of microfluidic spinning compact discs with embedded trapezoidal microchambers for the purpose of inertial microparticle focusing is reported in this article. Microparticle focusing channels require small features that cannot be easily fabricated in acrylic sheets and are complicated to realize in glass by traditional lithography techniques; therefore, the fabrication of microfluidic discs with femtosecond laser ablation is reported for the first time in this paper. It could be demonstrated that high-efficiency inertial focusing of 5 and 10 μm particles is achieved in a channel with trapezoidal microchambers regardless of the direction of disc rotation, which correlates to the dominance of inertial forces over Coriolis forces. To achieve the highest throughput possible, the suspension concentration was increased from 0.001% (w/v) to 0.005% (w/v). The focusing efficiency was 98.7% for the 10 μm particles and 93.75% for the 5 μm particles.",

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AU - Al-Halhouli, Ala’aldeen

AU - Doofesh, Zaid

AU - Albagdady, Ahmed

AU - Dietzel, Andreas

N1 - This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PY - 2020/1/30

Y1 - 2020/1/30

N2 - The fabrication and testing of microfluidic spinning compact discs with embedded trapezoidal microchambers for the purpose of inertial microparticle focusing is reported in this article. Microparticle focusing channels require small features that cannot be easily fabricated in acrylic sheets and are complicated to realize in glass by traditional lithography techniques; therefore, the fabrication of microfluidic discs with femtosecond laser ablation is reported for the first time in this paper. It could be demonstrated that high-efficiency inertial focusing of 5 and 10 μm particles is achieved in a channel with trapezoidal microchambers regardless of the direction of disc rotation, which correlates to the dominance of inertial forces over Coriolis forces. To achieve the highest throughput possible, the suspension concentration was increased from 0.001% (w/v) to 0.005% (w/v). The focusing efficiency was 98.7% for the 10 μm particles and 93.75% for the 5 μm particles.

AB - The fabrication and testing of microfluidic spinning compact discs with embedded trapezoidal microchambers for the purpose of inertial microparticle focusing is reported in this article. Microparticle focusing channels require small features that cannot be easily fabricated in acrylic sheets and are complicated to realize in glass by traditional lithography techniques; therefore, the fabrication of microfluidic discs with femtosecond laser ablation is reported for the first time in this paper. It could be demonstrated that high-efficiency inertial focusing of 5 and 10 μm particles is achieved in a channel with trapezoidal microchambers regardless of the direction of disc rotation, which correlates to the dominance of inertial forces over Coriolis forces. To achieve the highest throughput possible, the suspension concentration was increased from 0.001% (w/v) to 0.005% (w/v). The focusing efficiency was 98.7% for the 10 μm particles and 93.75% for the 5 μm particles.

KW - microfluidics

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KW - microfluidic disc

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High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc

Abstract

Bibliographical note

Funder

Keywords

ASJC Scopus subject areas

Access to Document

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