Heterocyclic Compounds For The Treatment Of Cystic Fibrosis

Jagdis Bala, Kamlesh (Inventor), Rebecca Butler (Inventor), Paul Collingwood, Stephen (Inventor), Charles Hall, Edward (Inventor), Lee Edwards (Inventor), Mark Legrand, Darren (Inventor), Katrin Spiegel (Inventor)

Research output: Patent


The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Original languageEnglish
Patent numberWO2013038386A1
Priority date16/09/11
Filing date14/09/12
Publication statusPublished - 21 Mar 2013
Externally publishedYes


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