TY - PAT
T1 - Heterocyclic Compounds For The Treatment Of Cystic Fibrosis
AU - Bala, Kamlesh, Jagdis
AU - Butler, Rebecca
AU - Collingwood, Stephen, Paul
AU - Hall, Edward, Charles
AU - Edwards, Lee
AU - Legrand, Darren, Mark
AU - Spiegel, Katrin
PY - 2013/3/21
Y1 - 2013/3/21
N2 - The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
AB - The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
UR - https://worldwide.espacenet.com/patent/search/family/047143988/publication/WO2013038386A1?q=WO2013038386
M3 - Patent
M1 - WO2013038386A1
Y2 - 2012/09/14
ER -