Heterocyclic Compounds for the Treatment of CF

Kamlesh Jagdis Bala; Rebecca Butler; Stephen Paul Collingwood; Edward Charles Hall; Lee Edwards; Darren Mark Legrand; Katrin Spiegel

Heterocyclic Compounds for the Treatment of CF

Kamlesh Jagdis Bala (Inventor)
, Rebecca Butler (Inventor)
, Stephen Paul Collingwood (Inventor)
, Edward Charles Hall (Inventor)
, Lee Edwards (Inventor)
, Darren Mark Legrand (Inventor)
, Katrin Spiegel (Inventor)

Novartis International AG
Novartis Institutes for Biomedical Research

Research output: Patent

Abstract

The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Original language	English
Patent number	US2014228376A1
IPC	A61K31/4439,A61K31/497,A61K45/06,C07D413/04,C07D417/04
Priority date	14/09/12
Filing date	14/09/12
Publication status	Published - 14 Aug 2014
Externally published	Yes

Cite this

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title = "Heterocyclic Compounds for the Treatment of CF",

abstract = "The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.",

author = "Bala, \{Kamlesh Jagdis\} and Rebecca Butler and Collingwood, \{Stephen Paul\} and Hall, \{Edward Charles\} and Lee Edwards and Legrand, \{Darren Mark\} and Katrin Spiegel",

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day = "14",

language = "English",

type = "Patent",

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TY - PAT

T1 - Heterocyclic Compounds for the Treatment of CF

AU - Bala, Kamlesh Jagdis

AU - Butler, Rebecca

AU - Collingwood, Stephen Paul

AU - Hall, Edward Charles

AU - Edwards, Lee

AU - Legrand, Darren Mark

AU - Spiegel, Katrin

PY - 2014/8/14

Y1 - 2014/8/14

N2 - The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

AB - The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

UR - https://patentimages.storage.googleapis.com/34/b5/aa/43fcbcf0d48fa7/US20140228376A1.pdf

M3 - Patent

M1 - US2014228376A1

Y2 - 2012/09/14

ER -

Heterocyclic Compounds for the Treatment of CF

Abstract

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