Heterocyclic Compounds for the Treatment of CF

Kamlesh Jagdis Bala (Inventor), Rebecca Butler (Inventor), Stephen Paul Collingwood (Inventor), Edward Charles Hall (Inventor), Lee Edwards (Inventor), Darren Mark Legrand (Inventor), Katrin Spiegel (Inventor)

Research output: Patent


The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Original languageEnglish
Patent numberUS2014228376A1
Priority date14/09/12
Filing date14/09/12
Publication statusPublished - 14 Aug 2014
Externally publishedYes


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