Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity-absence of VPRs in sheep liver

John Howl; Mark Wheatley

doi:10.1016/0742-8413(93)90202-V

Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity-absence of VPRs in sheep liver

John Howl
, Mark Wheatley

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

1. We have studied the binding characteristics of the hepatic VPRs expressed by rat, cow, pig, sheep and human and have demonstrated species heterogeneity. 2. These species differences are manifested as variation in the VPR capacity (rat > cow > pig > human > sheep), and in the affinity of these receptors for their natural ligand AVP (rat = human > pig = cow). 3. A single class of VPRs, with high affinity for AVP, is present in rat, cow, human and pig liver. In contrast, ovine hepatocytes do not express a VPR. 4. The affinity of the V_1a-selective antagonist d(CH₂)₅Tyr(Me)²AVP is highly dependent on the species utilised, such that rat > human > cow.

Original language	English
Pages (from-to)	247-250
Number of pages	4
Journal	Comparative Biochemistry and Physiology. Part C, Comparative
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/0742-8413(93)90202-V
Publication status	Published - Jun 1993

Funding

Acknowledgements-This work was supported by the Medical Research Council and The Wellcome Trust.

ASJC Scopus subject areas

Immunology
Pharmacology

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title = "Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity-absence of VPRs in sheep liver",

abstract = "1. We have studied the binding characteristics of the hepatic VPRs expressed by rat, cow, pig, sheep and human and have demonstrated species heterogeneity. 2. These species differences are manifested as variation in the VPR capacity (rat > cow > pig > human > sheep), and in the affinity of these receptors for their natural ligand AVP (rat = human > pig = cow). 3. A single class of VPRs, with high affinity for AVP, is present in rat, cow, human and pig liver. In contrast, ovine hepatocytes do not express a VPR. 4. The affinity of the V1a-selective antagonist d(CH2)5Tyr(Me)2AVP is highly dependent on the species utilised, such that rat > human > cow.",

author = "John Howl and Mark Wheatley",

year = "1993",

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doi = "10.1016/0742-8413(93)90202-V",

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T1 - Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity-absence of VPRs in sheep liver

AU - Howl, John

AU - Wheatley, Mark

PY - 1993/6

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N2 - 1. We have studied the binding characteristics of the hepatic VPRs expressed by rat, cow, pig, sheep and human and have demonstrated species heterogeneity. 2. These species differences are manifested as variation in the VPR capacity (rat > cow > pig > human > sheep), and in the affinity of these receptors for their natural ligand AVP (rat = human > pig = cow). 3. A single class of VPRs, with high affinity for AVP, is present in rat, cow, human and pig liver. In contrast, ovine hepatocytes do not express a VPR. 4. The affinity of the V1a-selective antagonist d(CH2)5Tyr(Me)2AVP is highly dependent on the species utilised, such that rat > human > cow.

AB - 1. We have studied the binding characteristics of the hepatic VPRs expressed by rat, cow, pig, sheep and human and have demonstrated species heterogeneity. 2. These species differences are manifested as variation in the VPR capacity (rat > cow > pig > human > sheep), and in the affinity of these receptors for their natural ligand AVP (rat = human > pig = cow). 3. A single class of VPRs, with high affinity for AVP, is present in rat, cow, human and pig liver. In contrast, ovine hepatocytes do not express a VPR. 4. The affinity of the V1a-selective antagonist d(CH2)5Tyr(Me)2AVP is highly dependent on the species utilised, such that rat > human > cow.

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DO - 10.1016/0742-8413(93)90202-V

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AN - SCOPUS:0027312635

SN - 0306-4492

VL - 105

SP - 247

EP - 250

JO - Comparative Biochemistry and Physiology. Part C, Comparative

JF - Comparative Biochemistry and Physiology. Part C, Comparative

IS - 2

ER -

Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity-absence of VPRs in sheep liver

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