Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity-absence of VPRs in sheep liver

John Howl, Mark Wheatley

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

1. We have studied the binding characteristics of the hepatic VPRs expressed by rat, cow, pig, sheep and human and have demonstrated species heterogeneity. 2. These species differences are manifested as variation in the VPR capacity (rat > cow > pig > human > sheep), and in the affinity of these receptors for their natural ligand AVP (rat = human > pig = cow). 3. A single class of VPRs, with high affinity for AVP, is present in rat, cow, human and pig liver. In contrast, ovine hepatocytes do not express a VPR. 4. The affinity of the V1a-selective antagonist d(CH2)5Tyr(Me)2AVP is highly dependent on the species utilised, such that rat > human > cow.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume105
Issue number2
DOIs
Publication statusPublished - Jun 1993

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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