TY - JOUR
T1 - Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity-absence of VPRs in sheep liver
AU - Howl, John
AU - Wheatley, Mark
PY - 1993/6
Y1 - 1993/6
N2 - 1. We have studied the binding characteristics of the hepatic VPRs expressed by rat, cow, pig, sheep and human and have demonstrated species heterogeneity. 2. These species differences are manifested as variation in the VPR capacity (rat > cow > pig > human > sheep), and in the affinity of these receptors for their natural ligand AVP (rat = human > pig = cow). 3. A single class of VPRs, with high affinity for AVP, is present in rat, cow, human and pig liver. In contrast, ovine hepatocytes do not express a VPR. 4. The affinity of the V1a-selective antagonist d(CH2)5Tyr(Me)2AVP is highly dependent on the species utilised, such that rat > human > cow.
AB - 1. We have studied the binding characteristics of the hepatic VPRs expressed by rat, cow, pig, sheep and human and have demonstrated species heterogeneity. 2. These species differences are manifested as variation in the VPR capacity (rat > cow > pig > human > sheep), and in the affinity of these receptors for their natural ligand AVP (rat = human > pig = cow). 3. A single class of VPRs, with high affinity for AVP, is present in rat, cow, human and pig liver. In contrast, ovine hepatocytes do not express a VPR. 4. The affinity of the V1a-selective antagonist d(CH2)5Tyr(Me)2AVP is highly dependent on the species utilised, such that rat > human > cow.
UR - http://www.scopus.com/inward/record.url?scp=0027312635&partnerID=8YFLogxK
U2 - 10.1016/0742-8413(93)90202-V
DO - 10.1016/0742-8413(93)90202-V
M3 - Article
C2 - 8103730
AN - SCOPUS:0027312635
SN - 0306-4492
VL - 105
SP - 247
EP - 250
JO - Comparative Biochemistry and Physiology. Part C, Comparative
JF - Comparative Biochemistry and Physiology. Part C, Comparative
IS - 2
ER -