Hemodynamic impacts of various types of stenosis inthe left coronary artery bifurcation: A patient-specific analysis

Thanapong Chaichana, Zhonghua Sun, James Jewkes

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This study investigates the hemodynamic changes to various types of coronary stenosis in the left coronary artery bifurcation, based on a patient-specific analysis. Twenty two patients with left coronary artery disease were included in this study. All stenoses involving the left coronary artery bifurcation were classified into four types, according to their locations: A) left circumflex (LCx) and left anterior descending (LAD), B) LCx only, C) left main stem only, and D) LAD only. Computational fluid dynamics (CFD) was performed to analyze the flow and wall shear stress (WSS) changes in all reconstructed left coronary geometries. Our results showed that the flow velocity and WSS were significantly increased at stenotic locations. High WSS was found at >70% lumen stenosis, which ranged from 2.5Pa to 3.5Pa. This study demonstrates that in patients with more than 50% stenosis in the left coronary artery bifurcation, WSS plays an important role in providing information about the extent of coronary atherosclerosis in the left coronary artery branch.

Original languageEnglish
Pages (from-to)447-452
Number of pages6
JournalPhysica Medica
Volume29
Issue number5
Early online date1 Mar 2013
DOIs
Publication statusPublished - Sep 2013
Externally publishedYes

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Hemodynamics
  • Wall shear stress

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Hemodynamic impacts of various types of stenosis inthe left coronary artery bifurcation: A patient-specific analysis'. Together they form a unique fingerprint.

  • Cite this